Microvascular Dysfunction Assessed by 82Rb PET/CT as a Diagnostic Tool of Chronic Active Myocarditis
Immune-related myocarditis may be challenging. We report the case of a 66-year-old man with a history of treated multiple myeloma by using immune checkpoint blockers, referred for angina. Coronary angiography was normal. [ 82 Rb]Rubidium PET/CT found diffuse abnormal stress myocardial blood flow and reserve and the apparition of epicardial calcifications. [ 68 Ga]Ga-DOTATOC PET/CT and CMR revealed chronic calcified myocarditis, which was confirmed by histology. This case emphasizes microvascular dysfunction in chronic active myocarditis as assessed by perfusion PET/CT.
Authors
- Aurélie Sannier (ORCID: https://orcid.org/0000-0003-3973-8793)
- Angela Malmare
- Phalla Ou (ORCID: https://orcid.org/0000-0002-2034-5001)
- Dimitri Arangalage (ORCID: https://orcid.org/0000-0002-0898-9090)
- Matthieu Bailly (ORCID: https://orcid.org/0000-0001-6526-0813)
Institutions
- Université d'Orléans (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Paris Cardiovascular Research Center (FR)
- Laboratoire de Recherche Vasculaire Translationnelle (FR)
- Centre hospitalier universitaire d'Orléans (FR)
- Hôpital Bichat-Claude-Bernard (FR)
Publication Details
- Journal
- Clinical Nuclear Medicine
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1097/rlu.0000000000006159
- Primary Topic
- Pericarditis and Cardiac Tamponade
- Type
- article
- Field-Weighted Citation Impact
- 0.00