Polygenic pathways shape white matter vulnerability to Alzheimer’s disease-related pathophysiological changes
Pathway-specific genetic vulnerability to AD is associated with alterations in WM tracts both directly and by moderating the effects of AD-related pathophysiological changes. AD-associated genetic risk should be integrated into the AD diagnostic framework to enable targeted screening and intervention for future preclinical trials aimed at specific biological pathways.
Authors
- Emma S. Luckett (ORCID: https://orcid.org/0000-0003-1777-4742)
- Lyduine E. Collij (ORCID: https://orcid.org/0000-0001-6263-1762)
- Joanna Marguerite Wardlaw (ORCID: https://orcid.org/0000-0002-9812-6642)
- Tiago Gil Oliveira (ORCID: https://orcid.org/0000-0003-0509-0562)
- Luca Roccatagliata (ORCID: https://orcid.org/0000-0001-8029-3947)
- Luigi Lorenzini (ORCID: https://orcid.org/0000-0002-9756-881X)
- Mario Tranfa (ORCID: https://orcid.org/0000-0002-4451-4746)
- Giuseppe Pontillo (ORCID: https://orcid.org/0000-0001-5425-1890)
- Craig Ritchie (ORCID: https://orcid.org/0000-0002-6202-6906)
- Henk J. M. M. Mutsaerts (ORCID: https://orcid.org/0000-0003-0894-0307)
- Pierre Payoux (ORCID: https://orcid.org/0000-0002-1374-1620)
- Henne Holstege (ORCID: https://orcid.org/0000-0002-7688-3087)
- Pablo Martínez‐Lage
- Marcel Reinders (ORCID: https://orcid.org/0000-0002-1148-1562)
- Adam Waldman (ORCID: https://orcid.org/0000-0003-4398-6431)
- Gemma Salvadó (ORCID: https://orcid.org/0000-0002-5210-9230)
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Juan Domingo Gispert (ORCID: https://orcid.org/0000-0002-6155-0642)
- André Altmann (ORCID: https://orcid.org/0000-0002-9265-2393)
- Matteo Pardini (ORCID: https://orcid.org/0000-0002-4740-1982)
- Alle Meije Wink (ORCID: https://orcid.org/0000-0002-8197-0118)
- Arturo Brunetti (ORCID: https://orcid.org/0000-0001-7057-3494)
- Leonard Pieperhoff (ORCID: https://orcid.org/0009-0003-9003-4588)
- Niccoló Tesi (ORCID: https://orcid.org/0000-0002-1413-5091)
- Natalia Vilor-Tejedor
Institutions
- Allen Institute for Brain Science (US)
- Université Toulouse III - Paul Sabatier (FR)
- Radboud University Nijmegen (NL)
- Inserm (FR)
- Queen Mary University of London (GB)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- Malmö University (SE)
- Lund University (SE)
- Western General Hospital (GB)
- Vlaams Instituut voor Biotechnologie (BE)
- Radboud University Medical Center (NL)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Center for Human Genetics (US)
- Pasqual Maragall Foundation (ES)
- Amsterdam Neuroscience (NL)
- Federico II University Hospital (IT)
- Public Health Scotland (GB)
- UK Dementia Research Institute (GB)
- Spanish National Centre for Cardiovascular Research (ES)
- Hospital Del Mar (ES)
- Centre for Genomic Regulation (ES)
- Hospital Braga (PT)
- Ospedale Policlinico San Martino (IT)
- National Hospital for Neurology and Neurosurgery (GB)
- Amsterdam University Medical Centers (NL)
- Fundacion CITA Alzheimer (ES)
- Hôpital Paule de Viguier (FR)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- University College London (GB)
- Imperial College London (GB)
- University of Naples Federico II (IT)
- University of Genoa (IT)
- Delft University of Technology (NL)
- University of Edinburgh (GB)
- KU Leuven (BE)
- University of Minho (PT)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1186/s13195-025-01888-3
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- EU Joint Programme – Neurodegenerative Disease Research
- European Federation of Pharmaceutical Industries and Associations
- Rijksdienst voor Ondernemend Nederland
- Alzheimer's Society
- British Heart Foundation
- European Commission
- Fondation Leducq
- ZonMw
- Ministerio de Ciencia e Innovación
- Alzheimer Nederland
- UK Dementia Research Institute
- Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona
- Medical Research Council
- Eurostars