Novel antimicrobial strategy: native postbiotics synergize with antibiotics to overcome resistance in Klebsiella pneumoniae
Our findings demonstrate that native postbiotics, particularly in synergy with antibiotics, exert potent antimicrobial activity against multidrug-resistant K. pneumoniae and effectively downregulate critical resistance genes; highlighting the potential of postbiotics as adjunctive therapeutic agents in the battle against AMR.
Authors
- Farzad Badmasti (ORCID: https://orcid.org/0000-0003-3502-147X)
- Shadi Aghamohammad (ORCID: https://orcid.org/0000-0003-1832-3695)
- Elham Haj Agha Gholizadeh Khiavi
- Mahdi Rohani
- Fatemeh Sakaki
- Zahra Haghighatshenas
Institutions
- Pasteur Institute of Iran (IR)
- Islamic Azad University, Science and Research Branch (IR)
- University of Tehran (IR)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1186/s12866-025-04474-7
- Citations
- 2
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.18
Funders
- Pasteur Institute of Iran