Treatment of infertility and risk of breast cancer among women with a BRCA pathogenic variant: a matched case-control study
Findings from this large, international study found no evidence for an association between infertility or fertility treatment and the risk of breast cancer among BRCA1 or BRCA2 carriers. Although based on low rates of exposure, these findings provide some reassurance to BRCA carriers considering fertility treatment. Future studies evaluating impact of contemporary protocols are needed.
Authors
- Emily Thain (ORCID: https://orcid.org/0000-0002-8347-9998)
- Christian Fridolin Singer (ORCID: https://orcid.org/0000-0003-1294-0027)
- Fergus J. Couch (ORCID: https://orcid.org/0000-0001-9417-9985)
- Linda Steele (ORCID: https://orcid.org/0000-0003-3628-2022)
- Jan Lubiński (ORCID: https://orcid.org/0000-0003-2931-3003)
- Leigha Senter (ORCID: https://orcid.org/0000-0001-9270-8847)
- Tomasz Huzarski (ORCID: https://orcid.org/0000-0003-3857-4854)
- Antonella Rastelli
- William D. Foulkes (ORCID: https://orcid.org/0000-0001-7427-4651)
- Louise Bordeleau (ORCID: https://orcid.org/0000-0003-2111-0228)
- Tuya Pal (ORCID: https://orcid.org/0000-0001-8009-2475)
- Kevin Sweet
- Howard M. Saal (ORCID: https://orcid.org/0000-0002-0277-4777)
- Joanne L. Blum (ORCID: https://orcid.org/0000-0002-7951-6645)
- Karen Glass (ORCID: https://orcid.org/0009-0002-5927-6266)
- Tracy Graham
- Laura Rodríguez Redondo (ORCID: https://orcid.org/0009-0008-3528-6973)
- Shana Kim
- Robert E. Reilly
- Amber M. Aeilts (ORCID: https://orcid.org/0000-0001-8907-7853)
- Christine Elser (ORCID: https://orcid.org/0000-0003-0003-713X)
- Marta Seca (ORCID: https://orcid.org/0000-0003-1944-0842)
- Olufunmilayo I. Olopade (ORCID: https://orcid.org/0000-0002-9936-1599)
- Kim Serfas
- Raymond H. Kim (ORCID: https://orcid.org/0000-0002-2147-8674)
- Susan L. Neuhausen (ORCID: https://orcid.org/0000-0001-5053-0390)
- Ellen Warner (ORCID: https://orcid.org/0000-0002-7956-6845)
- Carey A. Cullinane
- Robert Fruscio (ORCID: https://orcid.org/0000-0001-5688-2194)
- Andrea Eisen (ORCID: https://orcid.org/0000-0001-8037-9556)
- Stefania Zovato (ORCID: https://orcid.org/0000-0002-4295-3577)
- Georgia L. Wiesner (ORCID: https://orcid.org/0000-0001-8897-7008)
- Daniel Rayson (ORCID: https://orcid.org/0000-0002-2438-3128)
- Seema Panchal
- Beth Y. Karlan (ORCID: https://orcid.org/0000-0002-9451-2933)
- Stephanie A. Cohen (ORCID: https://orcid.org/0000-0002-5730-8642)
- Cezary Cybulski (ORCID: https://orcid.org/0000-0002-2819-3057)
- Joanne Kotsopoulos (ORCID: https://orcid.org/0000-0001-9624-4218)
- Pål Møller (ORCID: https://orcid.org/0000-0001-8211-8237)
- Jacek Gronwald (ORCID: https://orcid.org/0000-0002-3643-2871)
- Intan Schraeder
- Ping Sun (ORCID: https://orcid.org/0000-0003-4607-0592)
- Larissa Peck (ORCID: https://orcid.org/0009-0006-0551-7940)
- Sophie Sun (ORCID: https://orcid.org/0000-0002-2202-5060)
- Steven A. Narod
- Nadine Tung
- Aletta Poll
- Edmond G. Lemire
- Susan L. Neuhausen
- L J Mercer
- J.S. Dungan
Institutions
- Oslo University Hospital (NO)
- Beth Israel Deaconess Medical Center (US)
- Sunnybrook Health Science Centre (CA)
- University Health Network (CA)
- Mayo Clinic (US)
- University of California, Los Angeles (US)
- University of Toronto (CA)
- Juravinski Cancer Centre (CA)
- Norwegian Cancer Society (NO)
- Women's College Hospital (CA)
- Princess Margaret Cancer Centre (CA)
- The Ohio State University Wexner Medical Center (US)
- University of Chicago (US)
- Comprehensive Cancer Center Vienna (AT)
- City of Hope (US)
- Azienda Ospedaliera San Gerardo (IT)
- Public Health Ontario (CA)
- CReATe Fertility Centre (CA)
- International Hereditary Cancer Center (PL)
- Beckman Research Institute
- McGill University (CA)
- The Ohio State University (US)
- University of Milano-Bicocca (IT)
- Medical University of Vienna (AT)
- Pomeranian Medical University (PL)
- Vanderbilt University Medical Center (US)
- McMaster University (CA)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1186/s12885-025-15146-0
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00