RIPK3 is spatially associated with cartilage degeneration in osteoarthritis: integrative transcriptomic and histological analysis
RIPK3 is spatially enriched in degenerative regions of OA cartilage and associates with histopathological damage, suggesting its potential involvement in disease progression. These findings provide new insight into the molecular landscape of OA and support RIPK3 for further evaluation as a biomarker and potential therapeutic target.
Authors
- Lei Niu (ORCID: https://orcid.org/0000-0002-3343-1726)
- Lang Wu (ORCID: https://orcid.org/0000-0003-0933-8270)
- Guanghui Wang (ORCID: https://orcid.org/0000-0001-8551-6468)
- Wei Zhao (ORCID: https://orcid.org/0000-0002-2434-193X)
- Lei Wang (ORCID: https://orcid.org/0000-0002-3368-2832)
- Zihua Li (ORCID: https://orcid.org/0009-0002-3421-7606)
- Jing Tang (ORCID: https://orcid.org/0000-0003-3100-1842)
Institutions
- Ningxia Medical University (CN)
- Ningxia Center for Diseases Prevention and Control (CN)
- The Fourth People's Hospital of Ningxia Hui Autonomous Region (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1186/s13018-025-06321-x
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00