Truncated APC impairs innate immune response by targeting MAVS on mitochondria in colorectal cancer
Our study reveals a previously unrecognized role of Trunc-APC in dampening tumor-intrinsic innate immunity and suggests that co-targeting Trunc-APC with epigenetic therapy may offer a promising strategy to enhance anti-tumor immune responses in CRC.
Authors
- Fengwei Wang (ORCID: https://orcid.org/0000-0003-3886-7331)
- Yongrui Lv
- Jinghua Cao
- Xin-Yi Wang (ORCID: https://orcid.org/0009-0004-9279-5732)
- Dan Xie
- Jing Wang (ORCID: https://orcid.org/0000-0002-0398-862X)
- Siyu Li (ORCID: https://orcid.org/0000-0003-4960-190X)
Institutions
- Sun Yat-sen University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1186/s12967-025-07286-5
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China