Neuroglobin-promoted autophagy inhibits the proliferation, migration and invasion of human glioblastoma cells through the EGFR/PI3K/AKT/mTOR signaling pathway
In this study, our research findings indicated that Ngb promoted autophagy and suppressed the migration and invasion of GBM cells through inactivation of the EGFR/PI3K/AKT/m-TOR signaling pathway, highlighting that autophagy activation may suppress the invasion of GBM cells with low Ngb expression.
Authors
- Zhenzhao Luo (ORCID: https://orcid.org/0000-0002-9463-9184)
- Zhijun Yuan (ORCID: https://orcid.org/0009-0009-0302-2014)
- Wenxue Zhao (ORCID: https://orcid.org/0000-0001-5380-1176)
- Li Li (ORCID: https://orcid.org/0000-0002-9805-3957)
- Wenqing Li (ORCID: https://orcid.org/0000-0002-8336-5552)
- Hongfeng Zhang (ORCID: https://orcid.org/0009-0001-3186-3357)
Institutions
- Central Hospital of Wuhan (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1186/s12967-025-07283-8
- Citations
- 1
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Natural Science Foundation of China
- Health and Family Planning Commission of Wuhan Municipality