Design and biological evaluation of peptide disruptors targeting YAP1-TEAD interaction for oral cancer
This study developed a series of peptide disruptors targeting YAP1-TEAD protein interaction through computational simulations and in vitro experiments. The biological evaluation of two of these disruptors in OSCC confirmed that direct disruption of the YAP1-TEAD primarily affects the migration and invasion ability of oral cancer.
Authors
- Hao Yang (ORCID: https://orcid.org/0009-0008-0040-276X)
- Xianglei Zhang (ORCID: https://orcid.org/0000-0001-5175-8311)
- Yu Liu
- Chao Xu (ORCID: https://orcid.org/0000-0001-5520-4834)
- Li Liu (ORCID: https://orcid.org/0000-0003-2566-7357)
- Xi Yang (ORCID: https://orcid.org/0000-0002-7219-4591)
- Weijia Xu
- Yue Wu (ORCID: https://orcid.org/0000-0002-5413-0420)
- Guanying Feng (ORCID: https://orcid.org/0000-0002-7959-4846)
- Kailiu Wu
- Chenping Zhang (ORCID: https://orcid.org/0009-0002-4399-5792)
Institutions
- Shanghai Jiao Tong University (CN)
- ShanghaiTech University (CN)
- Shanghai Ninth People's Hospital (CN)
- National Clinical Research (US)
Publication Details
- Journal
- BMC Oral Health
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1186/s12903-025-07007-w
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- ShanghaiTech University