Whole-Exome Sequencing-Based Linkage Analysis of Multiple Myeloma (MM) and Monoclonal Gammopathy of Undetermined Significance (MGUS) Pedigrees
This study demonstrates the utility of applying a linkage analysis framework to familial WES data for identifying genomic regions and candidate genes that may contribute to MM/MGUS predisposition. These findings provide new insight into the inherited risk and etiology of familial MM and MGUS.
Authors
- Kenneth Offit (ORCID: https://orcid.org/0000-0002-2180-2032)
- Delphine Demangel (ORCID: https://orcid.org/0000-0001-6550-2827)
- Charles Dumontet (ORCID: https://orcid.org/0000-0003-1875-134X)
- Daniel O’Brien (ORCID: https://orcid.org/0000-0002-3540-3139)
- Joseph Vijai (ORCID: https://orcid.org/0000-0002-7933-151X)
- Robert J. Klein (ORCID: https://orcid.org/0000-0003-3539-5391)
- Aaron D. Norman (ORCID: https://orcid.org/0000-0002-4208-2708)
- Angel Earle
- Steven M. Lipkin (ORCID: https://orcid.org/0000-0002-0603-9139)
- Xiaomu Wei (ORCID: https://orcid.org/0000-0001-8331-6112)
- Jason P. Sinnwell (ORCID: https://orcid.org/0000-0003-1964-5522)
- Alyssa Clay‐Gilmour (ORCID: https://orcid.org/0000-0001-9998-4879)
- Celine M. Vachon
- S. Vincent Rajkumar (ORCID: https://orcid.org/0000-0002-5862-1833)
- Nicola J. Camp (ORCID: https://orcid.org/0000-0002-4788-1998)
- James McKay (ORCID: https://orcid.org/0000-0002-1787-3874)
- Siwei Chen (ORCID: https://orcid.org/0000-0003-1244-834X)
- Shaji Kumar
- R. L. Griffin (ORCID: https://orcid.org/0009-0007-5721-3727)
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Mayo Clinic (US)
- Memorial Sloan Kettering Cancer Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of South Carolina (US)
- Cornell University (US)
- University of Utah (US)
- Huntsman Cancer Institute (US)
- WinnMed (US)
- University of Chicago (US)
- Hospices Civils de Lyon (FR)
- Centre de Recherche en Cancérologie de Lyon (FR)
- Mayo Clinic in Florida (US)
- Centre international de recherche sur le cancer (FR)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Cancers
- Published
- 2025-11-10
- DOI
- https://doi.org/10.3390/cancers17223611
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Institut National Du Cancer
- National Institutes of Health
- National Cancer Institute