Gut Microbiota–Derived Tryptophan Indole Metabolites Ameliorate Collagen‐Induced Arthritis in Mice Via Aryl Hydrocarbon Receptor Activation
These findings indicate that tryptophan indole metabolites may play a negative regulatory role in the progression of RA by affecting Treg cell development and intestinal gut barrier function.
Authors
- Lvyi Chen (ORCID: https://orcid.org/0000-0002-4318-3033)
- Sijun Zhang
- Mario M. Zaiss (ORCID: https://orcid.org/0000-0003-3844-1664)
- Zhigang Tang (ORCID: https://orcid.org/0000-0002-6742-0654)
- Liang Wu (ORCID: https://orcid.org/0000-0002-2139-9378)
- Yubin Luo (ORCID: https://orcid.org/0000-0002-7669-1579)
- Yinlan Wu (ORCID: https://orcid.org/0000-0002-0188-8676)
- Aline Bözec (ORCID: https://orcid.org/0000-0001-8174-2118)
- Lingshu Zhang
- Chunyu Tan (ORCID: https://orcid.org/0009-0004-1068-5995)
- Tong Wu (ORCID: https://orcid.org/0000-0001-7188-2352)
- Qiuping Zhang (ORCID: https://orcid.org/0000-0002-4000-3957)
- Xing Ji (ORCID: https://orcid.org/0000-0003-1596-6003)
- Yanhong Li (ORCID: https://orcid.org/0000-0002-5449-729X)
Institutions
- Minzu University of China (CN)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Sichuan University (CN)
- Universitätsklinikum Erlangen (DE)
- West China Hospital of Sichuan University (CN)
- Zero to Three (US)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1002/art.43430
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81