Electroacupuncture Alleviates Brain Injury Through Vagus Nerve Activation and Gut Microbiota in a Rat Model of Ischemic Stroke
EA at ST36 produced neuroprotection through activating vagal efferent pathways to orchestrate intestinal mucosal repair via Fut2-mediated fucosylation, which reshape microbial ecosystems and attenuate neuroinflammation. These findings establish a previously unrecognized vagus nerve-gut-brain axis mechanism for stroke recovery, positioning microbiota-directed neuromodulation by EA as a translatable therapeutic strategy.
Authors
- X.S. Li (ORCID: https://orcid.org/0009-0003-5351-6457)
- Tian‐Ce Xu (ORCID: https://orcid.org/0009-0004-5855-8426)
- Jingjing Niu (ORCID: https://orcid.org/0000-0002-1236-1028)
- Zi‐Ai Zhao (ORCID: https://orcid.org/0000-0002-9368-8662)
- Q Zhao (ORCID: https://orcid.org/0009-0004-6130-6115)
- Dawei Chen (ORCID: https://orcid.org/0000-0002-7486-1992)
- Yue‐Xin Ning (ORCID: https://orcid.org/0009-0002-1805-8705)
- Yi‐Feng Pei (ORCID: https://orcid.org/0000-0003-2372-3343)
Institutions
- Shenyang Institute of Engineering (CN)
- General Hospital of Shenyang Military Region (CN)
- Command Hospital (IN)
- Shenyang University (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1161/jaha.125.045929
- Citations
- 2
- Primary Topic
- Vagus Nerve Stimulation Research
- Type
- article
- Field-Weighted Citation Impact
- 1.68