miR-499 in Platelet-Derived Extracellular Vesicles Augments Inflammatory Cell Generation and Cardiac Remodeling After Myocardial Infarction
Our study suggests that pEVs generated after MI induce HSPC proliferation and inflammatory cell generation. These discoveries uncover several therapeutic targets to reduce cardiac inflammation and remodeling after MI.
Authors
- Cristina Espinosa‐Díez
- Lee Ohayon
- Ebin Johny (ORCID: https://orcid.org/0000-0002-8857-9357)
- Dr Sheela Kurian
- Ankush Dasari
- Emilie Coppin (ORCID: https://orcid.org/0000-0001-8987-0050)
- Aarush Dutta
- Xinyi Zhang (ORCID: https://orcid.org/0000-0002-5846-337X)
- Mohammad A. Uddin
- Yoel Sadovsky (ORCID: https://orcid.org/0000-0003-2969-6737)
- Partha Dutta (ORCID: https://orcid.org/0000-0001-7456-1757)
- Erik S.G. Stroes (ORCID: https://orcid.org/0000-0001-9555-6260)
- Shagufta Haque (ORCID: https://orcid.org/0000-0002-8346-5844)
- Yingshi Ouyang (ORCID: https://orcid.org/0000-0002-8970-1297)
- Lotte C.A. Stiekema
- Bing Wang (ORCID: https://orcid.org/0000-0002-5185-3500)
- Niranjana Natarajan
Institutions
- University of Pittsburgh (US)
- Palo Alto University (US)
- Gene Therapy Laboratory (FR)
- Magee-Womens Research Institute (US)
- Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) (DE)
- University of Pittsburgh Medical Center (US)
- Second Affiliated Hospital of Zhejiang University (CN)
- Amsterdam University of Applied Sciences (NL)
- Technische Universität Dresden (DE)
- University of Amsterdam (NL)
Publication Details
- Journal
- Circulation
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1161/circulationaha.124.073527
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81