Subsecond dopamine fluctuations do not specify the vigor of ongoing actions
Dopamine (DA) is essential for the production of vigorous actions, but how DA modifies the gain of motor commands remains unclear. Here we show that subsecond DA transients in the striatum of mice are neither required nor sufficient for specifying the vigor of ongoing forelimb movements. Our findings have important implications for our understanding of how DA contributes to motor control under physiological conditions and in Parkinson's disease.
Authors
- Akhila Sankaramanchi (ORCID: https://orcid.org/0000-0002-1182-9573)
- Marta Maltese (ORCID: https://orcid.org/0000-0002-9084-0411)
- Nicolas X. Tritsch (ORCID: https://orcid.org/0000-0003-3181-7681)
- Riccardo Melani (ORCID: https://orcid.org/0000-0002-8206-8193)
- James Taniguchi
- Ruoheng Zeng
- Haixin Liu (ORCID: https://orcid.org/0000-0003-3217-856X)
- Jenna R. Martin
Institutions
- Douglas Mental Health University Institute (CA)
- McGill University Health Centre (CA)
- McGill University (CA)
- New York University (US)
Publication Details
- Journal
- Nature Neuroscience
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1038/s41593-025-02102-1
- Citations
- 2
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- McGill University
- York University
- Canada First Research Excellence Fund
- National Institutes of Health