C-Src/β-DG-mediated impairment of glia-vascular unit integrity via AQP4 depolarization contributes to secondary hydrocephalus after intraventricular hemorrhage
c-Src kinase has been markedly activated after IVH, triggering p-β-DG, facilitating its internalization and trafficking, and ultimately causing AQP4 depolarization. This disturbance in cerebrospinal fluid homeostasis stems from dysfunction of the GS, which contributes to the pathogenesis of hydrocephalus. Therefore, p-β-DG has been proposed as a critical molecular target for modulating glymphatic impairment after IVH.
Authors
- Gelei Xiao (ORCID: https://orcid.org/0000-0001-9234-0595)
- Kaiyue Wang
- Qian Ouyang
- Junqiang Wang (ORCID: https://orcid.org/0000-0001-5244-6483)
- Qinghua Zhang (ORCID: https://orcid.org/0000-0003-1067-4343)
- Zhikun Liu (ORCID: https://orcid.org/0000-0002-2327-6195)
- Yijian Yang
- Aijun Liang (ORCID: https://orcid.org/0009-0005-8923-3197)
- Yexin Yuan
- Libin Wang (ORCID: https://orcid.org/0000-0001-7422-0290)
- Liyang Zhang
Institutions
- Central South University (CN)
- Shenzhen Sixth People's Hospital (CN)
- ShenZhen People’s Hospital (CN)
- Jiangxi Chest Hospital (CN)
- Hunan Cancer Hospital (CN)
- Zhuzhou Central Hospital (CN)
- Xiangya Hospital Central South University (CN)
- Anshan Hospital (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1097/js9.0000000000003867
- Citations
- 1
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.91