Comparison of Efficacy and Durability of Three Desensitising Agents in Non Carious Non Restorable Lesions: A Randomised Clinical Study

Introduction: Dentin hypersensitivity arises from stimulus transmission across exposed dentin, leading to pain through a hydrodynamic mechanism. The primary goal in treating this condition is to provide immediate and lasting pain relief while restoring the impermeability of dentinal tubules. However, an ideal desensitising agent has yet to be identified. Aim: To compare the efficacy of Admira Protect, Gluma Desensitizer, and Seal&Protect as an antihypersensitive agent in non carious, non restorable lesions and the durability of the bond for one, three and six months. Materials and Methods: This randomised clinical study was carried out in the Department of Conservative Dentistry and Endodontics at K.M. Shah Dental College and Hospital, Vadodara, Gujarat, India, from January 2016 to July 2017, with 90 teeth from 27 patients randomly assigned to one of three groups, each containing at least 30 teeth with a Visual Analogue Scale (VAS) score of 4 or higher. Admira Protect-group A (n=30); Seal&Protectgroup B (n=30), and Gluma Desensitiser-group C (n=30). Dentin hypersensitivity was evaluated using tactile, thermal (cold), and evaporative stimuli at four time points: baseline, immediately after treatment, and at one, three, and six months post-treatment. Sensitivity levels were recorded using a VAS. The experimental agents were applied by a co-investigator per the manufacturer’s instructions, while the principal investigator assessed sensitivity at all time points. Data were analysed using One-way Analysis of Variance (ANOVA) and post-hoc Tukey tests. Results: All three treatment groups demonstrated significant differences (p-value <0.05) at baseline, immediately after treatment, and during the 3 months and 6 months follow-ups. A statistically significant difference was observed between Admira Protect (A) and Gluma Desensitiser (C). However, no significant differences were found between Admira Protect (A) and Seal&Protect (B), or between Seal&Protect (B) and Gluma Desensitiser (C). Overall, all three agents proved effective for approximately six months. Conclusion: Admira Protect demonstrated a statistically significantly greater reduction in dentin hypersensitivity compared to Gluma Desensitiser, particularly at immediate, 1-month, and 3-month assessments.