Mid-infrared photons relieve tinnitus-like behavior of mice by regulating HCN2 ion channels in the medial geniculate body
MIR intervention may alleviate the abnormal increase in neuronal firing frequency in the MGB of tinnitus mice by modulating HCN channel function. This regulatory mechanism involves influencing the secondary structure of HCN channels, enhancing hyperpolarization-activated current amplitude, and restoring reduced amplitudes observed in tinnitus mice.
Authors
- Yuke Jiang
- Xiaoxia Jiang (ORCID: https://orcid.org/0000-0003-1401-9653)
- Lan Sun (ORCID: https://orcid.org/0000-0002-3317-2154)
- Shuhan Lu
- Xinmiao Xue (ORCID: https://orcid.org/0000-0002-0005-4207)
- Zhiwei Ding (ORCID: https://orcid.org/0000-0003-3872-6512)
- Hanwen Zhou (ORCID: https://orcid.org/0000-0002-1161-1697)
- Shiming Yang (ORCID: https://orcid.org/0000-0002-7808-2566)
- Li Wang (ORCID: https://orcid.org/0000-0002-6813-8060)
- Peng Liu (ORCID: https://orcid.org/0000-0001-6965-8001)
- Xiaoming Li (ORCID: https://orcid.org/0000-0003-3899-7021)
- Zhixin Zhang (ORCID: https://orcid.org/0000-0003-1321-5273)
- Fangyuan Wang (ORCID: https://orcid.org/0000-0002-9880-3930)
- Chi Zhang (ORCID: https://orcid.org/0000-0002-6206-4160)
- Shen Weidong (ORCID: https://orcid.org/0000-0002-8962-8798)
Institutions
- Beijing Institute of Education (CN)
- Chinese PLA General Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Institute of Physiology and Basic Medicine (RU)
- National Clinical Research (US)
- Bethune International Peace Hospital (CN)
- PLA Academy of Military Science (CN)
- Institute of Pharmacology (CZ)
- Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1080/07853890.2025.2584694
- Primary Topic
- Photoreceptor and optogenetics research
- Type
- article
- Field-Weighted Citation Impact
- 0.00