Estimating the Accuracy and Additionality of TB-LAM to Diagnose TB in Children Without HIV (AccuLAM)
New diagnostic tests and alternative samples to diagnose tuberculosis in children are needed to tackle the diagnostic gap of pediatric tuberculosis. The Determine TB LAM Ag test in urine demonstrated sensitivity of 15.9% and specificity of 90.6%. Collecting the urine in adhesive bag was an independent risk factor for positivity (odds ratio, 11.38; P < .01).
Authors
- Sabine Hermans (ORCID: https://orcid.org/0000-0001-5146-2932)
- Willy Ssengooba (ORCID: https://orcid.org/0000-0002-1643-110X)
- Elisa López‐Varela (ORCID: https://orcid.org/0000-0002-6725-5687)
- Edson Mambuque (ORCID: https://orcid.org/0000-0002-9106-1444)
- Alexander Kay (ORCID: https://orcid.org/0000-0001-5283-4697)
- Shilzia Munguambe (ORCID: https://orcid.org/0000-0002-5433-727X)
- Anna M. Mandalakas (ORCID: https://orcid.org/0000-0002-8091-3509)
- Clement Gascua Adu-Gyamfi (ORCID: https://orcid.org/0000-0002-3190-9343)
- Christoph Lange (ORCID: https://orcid.org/0000-0002-9691-4741)
- Lucía Carratalá-Castro (ORCID: https://orcid.org/0000-0003-2355-6477)
- Alberto L. García‐Basteiro (ORCID: https://orcid.org/0000-0002-2038-5505)
- Sozinho Acácio (ORCID: https://orcid.org/0000-0002-3173-6446)
- Joanna Ehrlich (ORCID: https://orcid.org/0000-0001-7828-7222)
- Andrew R. DiNardo (ORCID: https://orcid.org/0000-0001-5990-6470)
- Durbbin Mulengwa (ORCID: https://orcid.org/0000-0003-0536-7859)
- Anca Vasiliù (ORCID: https://orcid.org/0000-0001-5336-7859)
- Abigail Seeger (ORCID: https://orcid.org/0009-0004-0149-6084)
- Helton Timoteo
Institutions
- Radboud University Nijmegen (NL)
- Baylor College of Medicine (US)
- Radboud University Medical Center (NL)
- Departament de Salut (ES)
- Baylor College of Medicine Children’s Foundation (UG)
- Radboud Institute for Molecular Life Sciences (NL)
- German Center for Infection Research (DE)
- Manhiça Health Research Centre (MZ)
- Amsterdam Institute for Global Health and Development (NL)
- Research Center Borstel - Leibniz Lung Center (DE)
- Children’s Foundation (GB)
- Barcelona Institute for Global Health (ES)
- Amsterdam University Medical Centers (NL)
- Ministry of Health (SZ)
- Universitat de Barcelona (ES)
- Makerere University (UG)
- University of Amsterdam (NL)
- University of Lübeck (DE)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1093/cid/ciaf525
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00