Human plasma-derived plasminogen replacement in type 1 plasminogen deficiency: a pediatric case with multisystemic manifestation

The article by D€onmez-Demir et al., ‘Novel plasminogen gene mutations in Turkish patients with type I plasminogen deficiency’, recently published in Blood Coagulation and Fibrinolysis[1], was read with great interest. The study’s authors expanded the mutational spectrum of the PLG gene in the Turkish population and emphasized the clinical heterogeneity and the timely recognition of this rare disorder. As highlighted in the discussion, treatment options for type 1 plasminogen deficiency remain limited, and management strategies, including plasminogen replacement therapy, are of particular clinical relevance. In this context, we wish to present our paediatric case demonstrating a multisystemic phenotype and favourable clinical response to human plasma-derived plasminogen replacement.