Neutrophil-to-lymphocyte ratio predicts inpatient gout recurrence: a large-scale multicenter retrospective cohort with machine-learning validation
Elevated NLR is a robust, accessible biomarker independently associated with inpatient gout recurrence. Its integration into clinical risk models enhances prediction accuracy and supports personalized inpatient gout recurrence prevention strategies.
Authors
- Shixian Chen (ORCID: https://orcid.org/0000-0002-7200-433X)
- Wendong Lin (ORCID: https://orcid.org/0000-0001-8443-5789)
- Fei Zhong (ORCID: https://orcid.org/0000-0003-3313-0904)
- Jiabao Xu (ORCID: https://orcid.org/0000-0002-1285-9408)
- Zheng Xu (ORCID: https://orcid.org/0000-0003-1283-6238)
- Hui Zhang (ORCID: https://orcid.org/0000-0001-8049-6525)
- Yixin Chen (ORCID: https://orcid.org/0000-0002-3704-4432)
- Qian Zhang (ORCID: https://orcid.org/0000-0001-9924-6024)
- Min Zhang (ORCID: https://orcid.org/0000-0003-1000-8762)
- Xiaoling Chen (ORCID: https://orcid.org/0000-0002-4353-2061)
- Juan Li (ORCID: https://orcid.org/0000-0002-2977-2966)
- Meng Li (ORCID: https://orcid.org/0009-0003-1444-8375)
- Qin Huang (ORCID: https://orcid.org/0000-0001-8971-3821)
- Cai Li (ORCID: https://orcid.org/0000-0002-3425-125X)
- Yaqi Chen (ORCID: https://orcid.org/0000-0002-4008-0274)
- Jiani Liu (ORCID: https://orcid.org/0000-0002-1396-0487)
- Zhipeng Cheng (ORCID: https://orcid.org/0000-0002-4657-251X)
- Ruifeng Lin
- Danning Xie
- Yi Yuan
- X. Xia
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Hunan University of Arts and Science (CN)
- Guangzhou University (CN)
- TCM-Intigrated Cancer Center of Southern Medical University (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-10
- DOI
- https://doi.org/10.3389/fimmu.2025.1688516
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 0.00