The Association Between rs2414096 of CYP19 Gene Polymorphism and Polycystic Ovary Syndrome (PCOS) in Iraqi Women

Background & Objective: Women of reproductive age suffer from Polycystic Ovarian Syndrome (PCOS). The present study was conducted to investigate the association between the SNP rs2414096 in the cytochrome P450 CYP19 gene and polycystic ovarian syndrome in Iraqi women.Materials & Methods: Blood samples were collected from Iraqi women with PCOS at the Maternity Teaching Hospital (Al-Batool) in Baquba city, Diyala Governorate, Iraq. Participants' ages ranged from 29 to 57 years. Genotyping was performed using PCR-based techniques with specific primers, and the association between genotypes and PCOS risk was assessed through Hardy-Weinberg Equilibrium (HWE). Data analysis was done using statistical tests. P<0.05 was considered statistically significant.Results: HWE analysis revealed no significant differences between the observed and expected genotype frequencies in both PCOS patients and healthy controls (P>0.8885, P>0.6377, respectively). A comparative analysis of genotype and allele frequencies showed no significant differences between the groups. The GA and AA genotypes of rs2414096 were more prevalent in both patients and healthy individuals and may be protective against PCOS (RR=0.88, 0.52). In contrast, the GG genotype was associated with an increased risk of PCOS (RR=2.32). Allele analysis suggested that the A allele may have a protective role, while the G allele may contribute to the development of PCOS.Conclusion: The SNP rs2414096 in the CYP19 gene may not significantly impact the development of PCOS in Iraqi women. Further studies of larger sample sizes are needed to confirm these findings