Monoclonal Immunotactoid Glomerulopathy Associated With Chronic Lymphocytic Leukemia: A Case Report

Immunotactoid glomerulopathy (ITG) is exceedingly rare in clinical practice. A majority of cases are associated with an underlying hematological disorder and specifically chronic lymphocytic leukemia (CLL). The treatment consists of managing the underlying disease and supportive therapy. We present the case of an 80-year-old patient with a history of CLL who presented with proteinuria and acute kidney injury and eventually developed hematuria. His renal biopsy revealed monoclonal ITG. He began a course of chemotherapy for CLL and achieved remission with improved renal function.

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Journal
Cureus
Published
2025-11-09
DOI
https://doi.org/10.7759/cureus.96452
Primary Topic
Amyloidosis: Diagnosis, Treatment, Outcomes
Type
article
Field-Weighted Citation Impact
0.00
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article

Monoclonal Immunotactoid Glomerulopathy Associated With Chronic Lymphocytic Leukemia: A Case Report

Jean Hou, Michael E. Lazarus, Sina Shafiei, Atefeh Kalantary et al.
Cureus
Amyloidosis: Diagnosis, Treatment, Outcomes
article

Monoclonal Immunotactoid Glomerulopathy Associated With Chronic Lymphocytic Leukemia: A Case Report

Jean Hou, Michael E. Lazarus, Sina Shafiei, Atefeh Kalantary, Gholamreza Badiee
article en

Abstract

Immunotactoid glomerulopathy (ITG) is exceedingly rare in clinical practice. A majority of cases are associated with an underlying hematological disorder and specifically chronic lymphocytic leukemia (CLL). The treatment consists of managing the underlying disease and supportive therapy. We present the case of an 80-year-old patient with a history of CLL who presented with proteinuria and acute kidney injury and eventually developed hematuria. His renal biopsy revealed monoclonal ITG. He began a course of chemotherapy for CLL and achieved remission with improved renal function.

CureusVol. 17(11)
Cedars-Sinai Medical Center (US), University of California, Los Angeles (US)
Openalex Percentile: Top 70%
Amyloidosis: Diagnosis, Treatment, Outcomes
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