Novel Finding of Retinal Aneurysmal Alterations in Patients Undergoing Fingolimod Therapy for Multiple Sclerosis
Fingolimod may contribute to unilateral retinal aneurysmal vascular changes in a subset of patients. Clinicians should remain vigilant for potential retinal vascular complications, and further research is needed to clarify the underlying mechanisms, the evolution and the long-term risks associated with fingolimod therapy. Notably, in the reported cases, the retinal aneurysmal alterations showed regression following the discontinuation of fingolimod, suggesting a potential reversibility of these changes upon cessation of treatment.
Authors
- Carmen Dell’Aquila (ORCID: https://orcid.org/0000-0003-4395-0818)
- Lucia Ziccardi (ORCID: https://orcid.org/0000-0002-5563-1243)
- Mattia D’Andrea (ORCID: https://orcid.org/0000-0001-9074-3964)
- Vincenzo Parisi (ORCID: https://orcid.org/0000-0001-9513-4092)
- Lucilla Barbano (ORCID: https://orcid.org/0000-0001-5120-8635)
- Feliciana Menna (ORCID: https://orcid.org/0000-0002-4347-6573)
Institutions
- University of Molise (IT)
- Saint Camillus International University of Health and Medical Sciences (IT)
- Fondazione G.B. Bietti (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Neurology and Therapy
- Published
- 2025-11-09
- DOI
- https://doi.org/10.1007/s40120-025-00854-3
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00