The non-steroidal mineralocorticoid receptor blocker esaxerenone reduces glomerular hyperfiltration and albuminuria
These findings suggest that esaxerenone restores TGF function via adenosine signaling, attenuating glomerular hyperfiltration and reducing albuminuria. This study provides novel insights into the albuminuria-lowering effects of MR blockade in DKD and supports the therapeutic potential of esaxerenone.
Authors
- Kengo Kidokoro (ORCID: https://orcid.org/0000-0002-4932-0166)
- Eriko Kajimoto
- Rie Tatsugawa
- János Peti‐Peterdi (ORCID: https://orcid.org/0000-0003-4092-6185)
- Naoki Kashihara (ORCID: https://orcid.org/0000-0002-9487-984X)
- David Z.I. Cherney (ORCID: https://orcid.org/0000-0003-4164-0429)
- Hajime Nagasu (ORCID: https://orcid.org/0000-0003-2549-4126)
- Masafumi Wada (ORCID: https://orcid.org/0000-0001-9278-6060)
- Masanobu Takasu (ORCID: https://orcid.org/0009-0006-9201-075X)
- Georgina Gyarmati (ORCID: https://orcid.org/0000-0003-3452-7970)
- Seiji Kishi (ORCID: https://orcid.org/0000-0001-6205-1661)
- Tamaki Sasaki (ORCID: https://orcid.org/0000-0002-1836-3294)
- Yoshihisa Wada
- Hiroshi Kitao
Institutions
- University of Southern California (US)
- University Health Network (CA)
- University of Toronto (CA)
- Kawasaki Medical School (JP)
- Kawasaki Medical School Hospital (JP)
Publication Details
- Journal
- Nephrology Dialysis Transplantation
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1093/ndt/gfaf232
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.00