Plasma NfL and GFAP in the preclinical stages of neurodegenerative diseases: insights from the UK Biobank
Plasma NfL and GFAP showed distinct pre-diagnostic profiles. NfL was associated with incident diagnosis of several neurodegenerative diseases, while GFAP was specific to AD, reinforcing its role in dementia. These results may help optimize the identification of target populations at risk of neurodegenerative diseases for future neuroprotective treatments.
Authors
- Andrea Quattrone (ORCID: https://orcid.org/0000-0003-2071-2083)
- Enrico Fratto (ORCID: https://orcid.org/0000-0003-3422-972X)
- Jolanda Buonocore (ORCID: https://orcid.org/0000-0002-3813-283X)
- Costanza Maria Cristiani (ORCID: https://orcid.org/0000-0002-7811-2083)
- Aldo Quattrone (ORCID: https://orcid.org/0000-0003-2001-957X)
- Camilla Calomino (ORCID: https://orcid.org/0009-0002-7936-8408)
- Mariagrazia Talarico (ORCID: https://orcid.org/0000-0002-7439-3973)
- Basilio Vescio (ORCID: https://orcid.org/0000-0002-7172-8520)
- Fulvia Arcuri (ORCID: https://orcid.org/0009-0009-3723-6096)
Institutions
- Magna Graecia University (IT)
- Institute of Molecular Bioimaging and Physiology (IT)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-11-09
- DOI
- https://doi.org/10.1007/s00415-025-13498-y
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00