Placebo rates in randomized clinical trials of ulcerative colitis: an individual patient data meta-analysis
These results enable future trials to incorporate design elements that reduce placebo rates as well as a precise benchmark for expected rates in clinical trials that do not include placebo.
Authors
- Remo Panaccione (ORCID: https://orcid.org/0000-0002-5247-940X)
- Vipul Jairath (ORCID: https://orcid.org/0000-0001-8603-898X)
- Parambir Dulai
- Virginia Solitano (ORCID: https://orcid.org/0000-0002-2935-6778)
- Christopher Ma (ORCID: https://orcid.org/0000-0002-4698-9948)
- Siddharth Singh (ORCID: https://orcid.org/0000-0002-6120-4010)
- Brian G. Feagan (ORCID: https://orcid.org/0000-0002-6914-3822)
- Rocío Sedaño (ORCID: https://orcid.org/0000-0002-3311-638X)
- Yuhong Yuan (ORCID: https://orcid.org/0000-0003-4374-3042)
- Guangyong Zou (ORCID: https://orcid.org/0000-0001-5773-4185)
- Jurij Hanžel (ORCID: https://orcid.org/0000-0003-3158-8014)
- Malcolm Hogan
- Sudheer Kumar Vuyyuru (ORCID: https://orcid.org/0000-0002-8281-3237)
- Silvio Danese
- Laurent Peyrin-Biroulet
- Bruce E. Sands
- John K MacDonald
- Neeraj Narula
Institutions
- Northwestern University (US)
- Western University (CA)
- Lawson Health Research Institute (CA)
- University of Calgary (CA)
- Ljubljana University Medical Centre (SI)
- Population Health Research Institute (CA)
- University of California San Diego (US)
- Centre Hospitalier Régional et Universitaire de Nancy (FR)
- Northwestern University (PH)
- Institut de Recherche en Santé Digestive (FR)
- IRCCS Ospedale San Raffaele (IT)
- Clinique Hartmann (FR)
- Northwestern Medicine (US)
- McMaster University (CA)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Journal of Crohn s and Colitis
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1093/ecco-jcc/jjaf191
- Citations
- 1
- Primary Topic
- Pain Management and Placebo Effect
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- Pfizer
- Teva Pharmaceutical Industries