Different diabetes types and pancreatic ductal adenocarcinoma: a Mendelian randomization and pathway/gene-set analysis
Our results from this genetic association study support that T2D, particularly the obesity and lipodystrophy mechanistic clusters, and MODY genomic susceptibility regions play a role in the etiology of PDAC.
Authors
- Phyllis J. Goodman (ORCID: https://orcid.org/0000-0001-9660-7074)
- Charles Kooperberg (ORCID: https://orcid.org/0000-0002-7986-8560)
- Federico Canzian (ORCID: https://orcid.org/0000-0002-4261-4583)
- Harvey A. Risch (ORCID: https://orcid.org/0000-0001-5337-3941)
- Howard D. Sesso (ORCID: https://orcid.org/0000-0002-9698-9954)
- James Yarmolinsky (ORCID: https://orcid.org/0000-0003-4371-0873)
- Alpa V. Patel (ORCID: https://orcid.org/0000-0001-9997-1218)
- Samuel O. Antwi (ORCID: https://orcid.org/0000-0003-2372-9489)
- Stephen K. Van Den Eeden (ORCID: https://orcid.org/0000-0002-5599-8387)
- Alan A. Arslan (ORCID: https://orcid.org/0000-0002-7775-8085)
- Xing Hua (ORCID: https://orcid.org/0000-0002-8346-5887)
- Demetrius Albanes (ORCID: https://orcid.org/0000-0001-8330-4293)
- Alison Patricia Klein (ORCID: https://orcid.org/0000-0003-2737-8399)
- Miranda R. Jones (ORCID: https://orcid.org/0000-0003-4863-104X)
- Diptavo Dutta (ORCID: https://orcid.org/0000-0002-6634-9040)
- William R. Bamlet (ORCID: https://orcid.org/0000-0003-2903-1284)
- Chirayu Mohindroo (ORCID: https://orcid.org/0000-0002-5825-3356)
- Núria Malats (ORCID: https://orcid.org/0000-0003-2538-3784)
- Sandra Pérdomo (ORCID: https://orcid.org/0000-0001-7740-8141)
- Laufey T. Ámundadóttir (ORCID: https://orcid.org/0000-0003-1859-8971)
- Steven Gallinger (ORCID: https://orcid.org/0000-0001-5004-8393)
- Brian M. Wolpin (ORCID: https://orcid.org/0000-0002-0455-1032)
- Loı̈c Le Marchand (ORCID: https://orcid.org/0000-0001-5013-980X)
- Rayjean J. Hung (ORCID: https://orcid.org/0000-0002-4486-7496)
- Pietro Ferrari (ORCID: https://orcid.org/0000-0001-9358-7338)
- Debra T. Silverman (ORCID: https://orcid.org/0000-0001-8894-0301)
- Shengchao A. Li (ORCID: https://orcid.org/0000-0001-9252-1492)
- Christopher A. Haiman (ORCID: https://orcid.org/0000-0002-0097-9971)
- Burcu F. Darst (ORCID: https://orcid.org/0000-0002-6205-4632)
- Miquel Porta (ORCID: https://orcid.org/0000-0003-1684-7428)
- Jiahui Wang (ORCID: https://orcid.org/0000-0002-4855-5094)
- Irene Orlow (ORCID: https://orcid.org/0000-0001-6234-6961)
- Ann L. Oberg (ORCID: https://orcid.org/0000-0003-2539-9807)
- Shilpa Katta
- Herbert Yu (ORCID: https://orcid.org/0000-0003-3950-4815)
- Rachael Z. Stolzenberg‐Solomon (ORCID: https://orcid.org/0000-0003-3698-7006)
- Emily White (ORCID: https://orcid.org/0000-0002-8935-6227)
- Kimmie Ng (ORCID: https://orcid.org/0000-0003-0631-1494)
- Rachel Ε. Neale (ORCID: https://orcid.org/0000-0001-7162-0854)
- Paul E. Brennan (ORCID: https://orcid.org/0000-0002-8950-7646)
- Kari G. Rabe (ORCID: https://orcid.org/0000-0002-7313-1875)
- Jun Zhong (ORCID: https://orcid.org/0009-0007-2813-6865)
- Laura E. Beane Freeman (ORCID: https://orcid.org/0000-0003-1294-4124)
- Gabriella Andreotti (ORCID: https://orcid.org/0000-0002-1096-3324)
- Annette Peters (ORCID: https://orcid.org/0000-0001-6645-0985)
- Robert C. Kurtz (ORCID: https://orcid.org/0009-0002-6493-3136)
- Melissa C. Southey (ORCID: https://orcid.org/0000-0002-6313-9005)
- Kala Visvanathan (ORCID: https://orcid.org/0000-0002-0582-8005)
- Michael Goggins (ORCID: https://orcid.org/0000-0002-4286-2296)
- Caroline Y. Um (ORCID: https://orcid.org/0000-0001-5449-6230)
- Julie E. Buring (ORCID: https://orcid.org/0000-0003-2648-8692)
- Steven C. Moore (ORCID: https://orcid.org/0000-0002-8169-1661)
- Nathaniel Rothman (ORCID: https://orcid.org/0000-0001-6924-0895)
- Yu Chen (ORCID: https://orcid.org/0000-0002-1519-4894)
- Jia Liu (ORCID: https://orcid.org/0000-0003-0512-2026)
- Haoyu Zhang (ORCID: https://orcid.org/0000-0001-6423-0444)
- María‐José Sánchez (ORCID: https://orcid.org/0000-0003-4817-0757)
- Peter Kraft
- Xiaoyu Wang (ORCID: https://orcid.org/0009-0005-5143-6909)
- Ting Zhang (ORCID: https://orcid.org/0000-0001-9231-1604)
- Edward L. Giovannucci (ORCID: https://orcid.org/0000-0002-6123-0219)
- Chen Yuan
- Mengmeng Du
- Verena Katzke
- Stephen J. Chanock
- Wei Zheng (ORCID: https://orcid.org/0009-0008-7731-248X)
- Paige M. Bracci
- Kai Yu
- Elizabeth A. Holly
- Xiao-Ou Shu
- Manal M. Hassan (ORCID: https://orcid.org/0000-0002-8413-449X)
Institutions
- Leidos (United States) (US)
- University of Southern California (US)
- University of Hawaiʻi at Mānoa (US)
- Universitat Autònoma de Barcelona (ES)
- Brigham and Women's Hospital (US)
- American Cancer Society (US)
- Bloomberg (United States) (US)
- Queensland Health (AU)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- University of Hawaii System (US)
- Memorial Sloan Kettering Cancer Center (US)
- Kaiser Permanente (US)
- The University of Texas MD Anderson Cancer Center (US)
- Harvard University (US)
- Johns Hopkins University (US)
- Queensland University of Technology (AU)
- The University of Queensland (AU)
- The University of Melbourne (AU)
- German Cancer Research Center (DE)
- University of California, San Francisco (US)
- Cancer Council Victoria (AU)
- Vanderbilt University (US)
- Lunenfeld-Tanenbaum Research Institute (CA)
- QIMR Berghofer Medical Research Institute (AU)
- Heidelberg University (DE)
- Jacksonville College (US)
- Yale University (US)
- NYU Langone Health (US)
- Fred Hutch Cancer Center (US)
- Spanish National Cancer Research Centre (ES)
- Cancer Center of Hawaii (US)
- Instituto de Investigación Biosanitaria de Granada (ES)
- Dana-Farber Cancer Institute (US)
- Monash Health (AU)
- National Cancer Institute (UA)
- Cancer Research Center (US)
- Frederick National Laboratory for Cancer Research (US)
- Hospital Del Mar (ES)
- Municipal Institute for Medical Research (ES)
- National Cancer Institute (US)
- Mayo Clinic in Florida (US)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Melbourne Health (AU)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- Medical Research Network (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- Department of Health and Human Services (US)
- Centre international de recherche sur le cancer (FR)
- University of Hawaii Cancer Center
- Division of Cancer Epidemiology and Genetics
- Leidos Biomedical Research Inc. (United States)
- Imperial College London (GB)
- Monash University (AU)
- New York University (US)
- Andalusian School of Public Health (ES)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1093/jnci/djaf308
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- California Department of Public Health
- Yale University
- Johns Hopkins University
- National Institutes of Health
- Centers for Disease Control and Prevention
- University of California, San Francisco
- Medical Research Council
- National Health and Medical Research Council
- National Cancer Institute