Different diabetes types and pancreatic ductal adenocarcinoma: a Mendelian randomization and pathway/gene-set analysis

Our results from this genetic association study support that T2D, particularly the obesity and lipodystrophy mechanistic clusters, and MODY genomic susceptibility regions play a role in the etiology of PDAC.

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Publication Details

Journal
JNCI Journal of the National Cancer Institute
Published
2025-11-08
DOI
https://doi.org/10.1093/jnci/djaf308
Primary Topic
Genetic Associations and Epidemiology
Type
article
Field-Weighted Citation Impact
0.00

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Different diabetes types and pancreatic ductal adenocarcinoma: a Mendelian randomization and pathway/gene-set analysis

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Different diabetes types and pancreatic ductal adenocarcinoma: a Mendelian randomization and pathway/gene-set analysis

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article en

Abstract

Our results from this genetic association study support that T2D, particularly the obesity and lipodystrophy mechanistic clusters, and MODY genomic susceptibility regions play a role in the etiology of PDAC.

JNCI Journal of the National Cancer InstituteVol. 118(3)
Leidos (United States) (US), University of Southern California (US), University of Hawaiʻi at Mānoa (US), Universitat Autònoma de Barcelona (ES), Brigham and Women's Hospital (US), American Cancer Society (US), Bloomberg (United States) (US), Queensland Health (AU), Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA), University of Hawaii System (US), Memorial Sloan Kettering Cancer Center (US), Kaiser Permanente (US), The University of Texas MD Anderson Cancer Center (US), Harvard University (US), Johns Hopkins University (US), Queensland University of Technology (AU), The University of Queensland (AU), The University of Melbourne (AU), German Cancer Research Center (DE), University of California, San Francisco (US), Cancer Council Victoria (AU), Vanderbilt University (US), Lunenfeld-Tanenbaum Research Institute (CA), QIMR Berghofer Medical Research Institute (AU), Heidelberg University (DE), Jacksonville College (US), Yale University (US), NYU Langone Health (US), Fred Hutch Cancer Center (US), Spanish National Cancer Research Centre (ES), Cancer Center of Hawaii (US), Instituto de Investigación Biosanitaria de Granada (ES), Dana-Farber Cancer Institute (US), Monash Health (AU), National Cancer Institute (UA), Cancer Research Center (US), Frederick National Laboratory for Cancer Research (US), Hospital Del Mar (ES), Municipal Institute for Medical Research (ES), National Cancer Institute (US), Mayo Clinic in Florida (US), Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES), Melbourne Health (AU), Centro de Investigación Biomédica en Red de Cáncer (ES), Medical Research Network (US), Sidney Kimmel Comprehensive Cancer Center (US), Department of Health and Human Services (US), Centre international de recherche sur le cancer (FR), University of Hawaii Cancer Center, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research Inc. (United States), Imperial College London (GB), Monash University (AU), New York University (US), Andalusian School of Public Health (ES)
U.S. Department of Health and Human Services, California Department of Public Health, Yale University, Johns Hopkins University, National Institutes of Health, Centers for Disease Control and Prevention, University of California, San Francisco, Medical Research Council, National Health and Medical Research Council, National Cancer Institute
Openalex Percentile: Top 65%
Genetic Associations and Epidemiology
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