Analysis of comprehensive genomic profiling test for Ewing sarcoma in pediatric patients and adults using the nationwide clinical and genomic database in Japan
Compared to previous reports, Japanese ES cases showed lower STAG2 and higher TP53 mutation frequencies. CDKN2A and CDKN2B deletions may serve as prognostic biomarkers indicating unfavorable outcomes.
Authors
- Eisuke Kobayashi (ORCID: https://orcid.org/0000-0001-5751-473X)
- Masachika Ikegami (ORCID: https://orcid.org/0000-0003-0491-7142)
- Hiroya Kondo (ORCID: https://orcid.org/0000-0002-4642-5448)
- Rina Kitada
- Yoshiyuki Suehara (ORCID: https://orcid.org/0000-0001-8206-3037)
- Noboru Yamamoto (ORCID: https://orcid.org/0000-0002-0787-2851)
- Takafumi Koyama (ORCID: https://orcid.org/0000-0001-5807-8458)
- Satoshi Kamio (ORCID: https://orcid.org/0000-0003-1824-3046)
- Shintaro Iwata (ORCID: https://orcid.org/0000-0002-2024-514X)
- Shinji Kohsaka (ORCID: https://orcid.org/0000-0001-8651-6136)
- Koichi Ogura (ORCID: https://orcid.org/0000-0001-6956-3117)
- Kuniko Sunami (ORCID: https://orcid.org/0000-0002-7137-5649)
- Akira Kawai (ORCID: https://orcid.org/0000-0002-1040-3706)
- Toshiyuki Takemori (ORCID: https://orcid.org/0000-0003-4330-7822)
- Shuhei Osaki
- Seiji Shimomura (ORCID: https://orcid.org/0000-0002-1176-989X)
Institutions
- Juntendo University (JP)
- National Cancer Centre Japan (JP)
- National Cancer Center (US)
- National Cancer Research Institute (GB)
Publication Details
- Journal
- Japanese Journal of Clinical Oncology
- Published
- 2025-11-09
- DOI
- https://doi.org/10.1093/jjco/hyaf174
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00