Clonal Hematopoiesis and Incident Heart Failure
Results of this cohort study suggest that CHIP, especially non-DNMT3A CHIP, was associated with incident HF. Other CHIP-associated comorbidities explained only a minority of the association between non-DNMT3A CHIP and HF. These findings suggest that CHIP is an HF risk factor and potential therapeutic target.
Authors
- Md Mesbah Uddin (ORCID: https://orcid.org/0000-0003-1846-0411)
- Spencer Flynn (ORCID: https://orcid.org/0000-0001-5854-3751)
- Michael C. Honigberg (ORCID: https://orcid.org/0000-0001-8630-5021)
- Art Schuermans (ORCID: https://orcid.org/0000-0001-8146-9692)
- Pradeep Natarajan (ORCID: https://orcid.org/0000-0001-8402-7435)
- Vincenzo Viscosi (ORCID: https://orcid.org/0000-0003-4189-1615)
- Tetsushi Nakao (ORCID: https://orcid.org/0000-0001-9979-2682)
- Peter Libby
Institutions
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
- KU Leuven (BE)
Publication Details
- Journal
- JAMA Cardiology
- Published
- 2025-11-09
- DOI
- https://doi.org/10.1001/jamacardio.2025.4603
- Citations
- 4
- Primary Topic
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.50