Secondary metabolites with anti-inflammatory activity isolated from a marine-derived fungus <i>Biscogniauxia</i> sp. 8703
Four new compounds (<b>1</b>-<b>4</b>), along with 22 known metabolites (<b>5</b>-<b>26</b>), were isolated from the fungus <i>Biscogniauxia</i> sp. 8703. The structures of the new compounds were elucidated based on NMR, MS, and ECD analysis. Compounds <b>1</b> and <b>2</b> were identified as heliannuol D analogs, which exhibited anti-inflammatory activity by inhibiting NO production in LPS-induced RAW 264.7 cell, with IC<sub>50</sub> values of 7.14 and 25.25 <i>μ</i>M, respectively.
Authors
- Senhua Chen (ORCID: https://orcid.org/0000-0002-5498-0206)
- Guangyuan Luo (ORCID: https://orcid.org/0000-0002-5964-9256)
- Litong Chen (ORCID: https://orcid.org/0000-0002-9797-296X)
- Qilin Wu (ORCID: https://orcid.org/0000-0002-7625-8919)
- Zhibo Hu (ORCID: https://orcid.org/0000-0001-7225-4673)
- Qing‐Mei He (ORCID: https://orcid.org/0000-0002-3973-7566)
- Lan Liu (ORCID: https://orcid.org/0000-0003-2765-4015)
- Jing Li (ORCID: https://orcid.org/0000-0002-5070-7317)
- Zheng Li (ORCID: https://orcid.org/0000-0002-7060-2213)
- Jun Chen (ORCID: https://orcid.org/0000-0003-2218-7382)
- Dan He (ORCID: https://orcid.org/0000-0002-6731-283X)
- Heng Guo
Institutions
- Sun Yat-sen University (CN)
- Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) (CN)
- Pearl River Hydraulic Research Institute (CN)
- Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai) (CN)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2025-11-09
- DOI
- https://doi.org/10.1080/10286020.2025.2576000
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00