Beta-Blockers after Myocardial Infarction with Normal Ejection Fraction
In this meta-analysis including individual-patient data from five randomized trials, beta-blocker therapy did not reduce the incidence of death from any cause, myocardial infarction, or heart failure in patients with an LVEF of at least 50% after myocardial infarction without other indications for beta-blockers. (Funded by Centro Nacional de Investigaciones Cardiovasculares Carlos III and others; PROSPERO database number, CRD420251119176.).
Authors
- Arnhild Bakken
- Therese Lucia Friis Holmager (ORCID: https://orcid.org/0000-0002-7667-7080)
- Morten Wang Fagerland (ORCID: https://orcid.org/0000-0003-4535-5043)
- Michael Mæng (ORCID: https://orcid.org/0000-0002-4310-6433)
- José A. Barrabés (ORCID: https://orcid.org/0000-0001-7062-6277)
- Takeshi Kimura (ORCID: https://orcid.org/0000-0001-8940-2206)
- Anna Meta Dyrvig Kristensen (ORCID: https://orcid.org/0000-0001-9608-7902)
- Stuart Pocock (ORCID: https://orcid.org/0000-0003-2212-4007)
- Borja Ibáñez (ORCID: https://orcid.org/0000-0002-5036-254X)
- Roberto Latini (ORCID: https://orcid.org/0000-0002-3729-4650)
- Kjell Vikenes
- Sergio Raposeiras‐Roubín (ORCID: https://orcid.org/0000-0002-6462-4715)
- Tomas Jernberg (ORCID: https://orcid.org/0000-0003-1695-379X)
- Patric Karlström (ORCID: https://orcid.org/0000-0002-2441-0245)
- Robin Hofmann (ORCID: https://orcid.org/0000-0002-8907-895X)
- Xavier Rosselló (ORCID: https://orcid.org/0000-0001-6783-8463)
- Michael Hecht Olsen (ORCID: https://orcid.org/0000-0003-2230-5780)
- Bertil Lindahl (ORCID: https://orcid.org/0000-0002-5795-0061)
- Theis Lange (ORCID: https://orcid.org/0000-0001-6807-8347)
- Jocelyne Benatar (ORCID: https://orcid.org/0000-0002-6724-8997)
- Valentı́n Fuster (ORCID: https://orcid.org/0000-0002-9043-9986)
- Troels Yndigegn (ORCID: https://orcid.org/0000-0002-8960-2125)
- David Erlinge (ORCID: https://orcid.org/0000-0003-3042-5766)
- Neiko Ozasa (ORCID: https://orcid.org/0000-0001-8138-5026)
- Massimo Piepoli (ORCID: https://orcid.org/0000-0003-1124-234X)
- Claes Held (ORCID: https://orcid.org/0000-0001-9402-7404)
- Eva Prescott (ORCID: https://orcid.org/0000-0002-4134-0349)
- John Munkhaugen (ORCID: https://orcid.org/0000-0001-6141-2162)
- Dan Atar
Institutions
- Uppsala University (SE)
- University of Copenhagen (DK)
- Oslo University Hospital (NO)
- University of Oslo (NO)
- Lund University (SE)
- University of Milan (IT)
- Mario Negri Institute for Pharmacological Research (IT)
- Aarhus University (DK)
- Drammen Hospital (NO)
- Haukeland University Hospital (NO)
- Frederiksberg Hospital (DK)
- Auckland City Hospital (NZ)
- Aarhus University Hospital (DK)
- University Hospital Complex Of Vigo (ES)
- Copenhagen University Hospital (DK)
- Copenhagen Municipal Hospital (DK)
- Spanish National Centre for Cardiovascular Research (ES)
- Karolinska Institutet (SE)
- London School of Hygiene & Tropical Medicine (GB)
- Stockholm South General Hospital (SE)
- IRCCS Policlinico San Donato (IT)
- Mount Sinai Hospital (US)
- Nara City Hospital (JP)
- Centro de Investigación Biomédica en Red (ES)
- Vall d'Hebron Hospital Universitari (ES)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- Ryhov Hospital Jönköping (SE)
- Hospital Universitario Son Espases (ES)
- Municipal Hirakata City Hospital (JP)
- University of Bergen (NO)
- Universitat de les Illes Balears (ES)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-11-09
- DOI
- https://doi.org/10.1056/nejmoa2512686
- Citations
- 15
- Primary Topic
- Acute Myocardial Infarction Research
- Type
- article
- Field-Weighted Citation Impact
- 20.82