Gastroesophageal Reflux Disease and Risk of Atrial Fibrillation/Flutter: Implications for Heart Failure Progression

Genetic liability to GERD independently increases AF/AFL risk, unaffected by obesity pathways. Considering the well-established role of AF/AFL in the pathogenesis and progression of HF, our findings position GERD as a potential modifiable target within the causal pathway. Identification and management of GERD may therefore contribute to reducing atrial arrhythmia burden and subsequent HF risk.