Impact of Early Intensive GDMT on LVEF Recovery and ICD Decision Making in de Novo HFrEF
Early and intensive GDMT optimization resulted in significant LVEF improvement within the first 3 months post-diagnosis for most patients. Those who failed to recover by this point exhibited limited improvement by 1 year. These findings suggest that the conventional 3 month window for ICD decision making remains appropriate, despite advancements in heart failure therapy.
Authors
- J Rigueira (ORCID: https://orcid.org/0000-0003-1014-537X)
- R Santos (ORCID: https://orcid.org/0000-0001-7965-1508)
- João R. Agostinho (ORCID: https://orcid.org/0000-0002-4778-5066)
- Fausto José Pinto (ORCID: https://orcid.org/0000-0002-8034-4529)
- Danilo Alvarenga Ferreira (ORCID: https://orcid.org/0009-0005-0841-5600)
- Dulce Brito (ORCID: https://orcid.org/0000-0003-1278-1847)
- Nuno Lousada
- Joana Brito (ORCID: https://orcid.org/0000-0001-6672-7542)
- Doroteia Silva
- Daniel Inácio Cazeiro (ORCID: https://orcid.org/0009-0004-0277-7398)
Institutions
- Hospital de Santa Maria (PT)
Publication Details
- Journal
- ESC Heart Failure
- Published
- 2025-11-09
- DOI
- https://doi.org/10.1002/ehf2.15443
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidade de Lisboa
- Fundação para a Ciência e a Tecnologia