Withdrawal of aspirin in patients with left ventricular assist device treated with vitamin K antagonists: impact of anticoagulation quality in the randomized ARIES-HM3 trial
The quality of VKA management as measured by TTR correlates with the occurrence of non-surgical bleeding in patients with the HM3 LVAD, with a lower TTR associated with an increased bleeding risk. These data provide new clinical direction to define a benchmark TTR to achieve further mitigation of residual risk of bleeding and enhance haemocompatibility with the HM3 LVAD.
Authors
- Nourdine Chakouri (ORCID: https://orcid.org/0000-0002-8809-8684)
- Finn Gustafsson (ORCID: https://orcid.org/0000-0003-2144-341X)
- Nir Y. Uriel (ORCID: https://orcid.org/0000-0003-2301-3587)
- Ulrich P. Jorde (ORCID: https://orcid.org/0000-0002-9476-6466)
- Daniel Zimpfer (ORCID: https://orcid.org/0000-0002-2185-4895)
- Ashwin Ravichandran (ORCID: https://orcid.org/0000-0003-2571-4432)
- Rebecca Cogswell (ORCID: https://orcid.org/0000-0001-5250-1198)
- Manreet Kanwar (ORCID: https://orcid.org/0000-0002-7280-5268)
- Nick Dirckx (ORCID: https://orcid.org/0000-0003-1674-6715)
- Francis D. Pagani (ORCID: https://orcid.org/0000-0003-4430-9969)
- Farooq H. Sheikh (ORCID: https://orcid.org/0000-0001-9687-9475)
- Mandeep R. Mehra (ORCID: https://orcid.org/0000-0001-8683-7044)
- Jennifer Conway (ORCID: https://orcid.org/0000-0003-4051-2185)
- Jean M. Connors (ORCID: https://orcid.org/0000-0001-6445-582X)
- Ivan Netuka (ORCID: https://orcid.org/0000-0002-1567-7036)
- ERIC D. ADLER (ORCID: https://orcid.org/0000-0002-4765-0188)
- Mirnela Byku (ORCID: https://orcid.org/0000-0002-4541-5053)
- J. Ransom (ORCID: https://orcid.org/0000-0003-1175-4724)
- Michael M. Givertz (ORCID: https://orcid.org/0000-0003-1012-7710)
- Anita Phancao (ORCID: https://orcid.org/0000-0002-4294-8524)
- Richa Agarwal (ORCID: https://orcid.org/0000-0002-3615-9377)
- Jason N. Katz (ORCID: https://orcid.org/0000-0001-8557-4641)
- Eugene Chung (ORCID: https://orcid.org/0000-0002-5406-8874)
- Shelley Hall (ORCID: https://orcid.org/0000-0002-5989-2934)
- Jonathan Grinstein
- Hassan Nemeh
Institutions
- University of North Carolina at Chapel Hill (US)
- Brigham and Women's Hospital (US)
- Albert Einstein College of Medicine (US)
- Allegheny Health Network (US)
- Montefiore Medical Center (US)
- University of Alberta (CA)
- Baylor University (US)
- Georgetown University (US)
- University of Michigan (US)
- Vanguard College (CA)
- St Vincent Hospital (US)
- American Orchid Society (US)
- UC San Diego Health System (US)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Henry Ford Hospital (US)
- University of Chicago (US)
- Abbott (United States) (US)
- Baptist Health Foundation (US)
- St. Vincent Hospital (US)
- Bellevue Hospital Center (US)
- Heart Hospital Baylor Plano (US)
- Montefiore Health System (US)
- Michigan Medicine (US)
- Duke Medical Center (US)
- Institute of Clinical and Experimental Medicine (CZ)
- Christ Hospital (US)
- University of Minnesota Medical Center (US)
- Abbott Fund (US)
- MedStar Heart & Vascular Institute (US)
- Baylor Jack and Jane Hamilton Heart and Vascular Hospital (US)
- Medical University of Vienna (AT)
- Columbia University (US)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1093/eurheartj/ehaf745
- Citations
- 4
- Primary Topic
- Mechanical Circulatory Support Devices
- Type
- article
- Field-Weighted Citation Impact
- 2.70
Funders
- Abbott Laboratories
- Abiomed