What is the risk of asthma exacerbation for pregnant patients with a history of asthma who are put on labetalol for hypertension?

There may be an increased risk of asthma exacerbation when labetalol is used to treat hypertension in pregnant patients with a history of asthma (SOR: C, 1 cohort study and 1 case report). Compared with other antihypertensives, labetalol increases the risk of status asthmaticus in this population (SOR: C, 1 cohort study). Guidelines recommend avoiding the use of labetalol because of the risk of causing bronchospasm (SOR: C, 1 practice bulletin and 1 guideline).