Kocatepe Gebe Düvelerde İnaktif Parapoxvirus Ovis Uygulamasinin Kolostrum ve Buzaği Sağliği Üzerine İmmunmodulatorik Etkileri

The aim of this study was to evaluate the effect of inactive Parapoxvirus ovis (IPPVO) immunomodulation protocol administration to pregnant heifers in the third trimester of pregnancy on colostrum quality, passive transfer success and calf health. Animal material of the study included 40 Holstein breed pregnant heifers and their calves, 20 of them was IPPVO group and rest 20 was control group. Totally 3 doses of 2 ml IPPVO (Zylexis, Zoetis, USA) was administered intramuscularly to study group in 25, 23 and 21 days before estimated birth date. Also control group was injected the same amount of isotonic NaCI %0.9 with IPPVO in the same days. Colostrum samples from heifers after birth and blood samples from calves 24-48 hours after birth were taken and sera were extracted. Immunoglobulin G (Ig G) concentrations of colostrum and serum samples were measured by using enzyme linked immunoassay (ELISA) method. Calves’ health status were observed during first 30 days. There was no adverse effect was detected in heifers administered IPPVO during study procedure. IgG concentrations of heifers that received IPPVO was 59.64 mg/ml; that of control group was 59.62 mg/ml and the difference between groups was statistically insignificant (p>0.05). Average serum IgG concentration of calves born from heifers that received IPPVO was 32.6 mg/ml; that of control group was 28.7 mg/ml. When the yielded results of daily health status controls of two claves groups evaluated, no statistically significant difference was detected in terms of developing any disease and calf deaths (p>0.05).