H3K56 lactylation promotes collagen II synthesis to modulate chondrocyte metabolism in posttraumatic osteoarthritis
The glycolytic lactate/H3K56la/HIF 1α regulatory axis plays a positive regulatory role in the synthesis of type II collagen in chondrocytes by facilitating the binding of HIF 1α to the Col2a1 gene promoter. Activation of this molecular pathway holds promise as a novel therapeutic strategy for the treatment of posttraumatic osteoarthritis.
Authors
- Zicai Dong (ORCID: https://orcid.org/0000-0002-5485-5763)
- Shiwu Dong (ORCID: https://orcid.org/0000-0002-5032-4893)
- Xiaoshan Gong (ORCID: https://orcid.org/0009-0005-8690-4696)
- Guangyun Hu
- Zeyu Yang (ORCID: https://orcid.org/0000-0002-7223-5234)
- Qijie Dai (ORCID: https://orcid.org/0009-0002-4724-9180)
- Rujie Wang (ORCID: https://orcid.org/0000-0001-7144-1450)
- Qin Shu (ORCID: https://orcid.org/0000-0003-2047-4417)
- Hao Tang (ORCID: https://orcid.org/0000-0002-3932-4016)
- Chuan Yang
- Weiguo Kong (ORCID: https://orcid.org/0009-0000-0432-8810)
- Chunrong Zhao
- Di Liu (ORCID: https://orcid.org/0000-0003-3693-2726)
Institutions
- Army Medical University (CN)
- Daping Hospital (CN)
- Xinqiao Hospital (CN)
- Southwest Hospital (CN)
- First People's Hospital of Chongqing (CN)
Publication Details
- Journal
- Burns & Trauma
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1093/burnst/tkaf073
- Citations
- 1
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.67