Cold-induced serum short-chain fatty acids act as markers of brown adipose tissue metabolism in humans
Circulating SCFAs are linked with BAT oxidative metabolism and NEFA uptake during cold exposure. The observed correlations between SCFA catabolic genes and thermogenic markers suggest that metabolically active BAT may selectively engage SCFA-related pathways, pointing to a potential mechanistic role of SCFAs in supporting BAT function in humans.
Authors
- Vanessa D. de Mello (ORCID: https://orcid.org/0000-0003-3414-6983)
- Martin Klingenspor (ORCID: https://orcid.org/0000-0002-4502-6664)
- Milena Monfort‐Pires (ORCID: https://orcid.org/0000-0002-1652-8083)
- Juho Raiko (ORCID: https://orcid.org/0000-0001-8879-4738)
- Johan Rajander (ORCID: https://orcid.org/0000-0003-3591-0963)
- Mueez U-Din (ORCID: https://orcid.org/0000-0002-8242-3079)
- Kati Hanhineva (ORCID: https://orcid.org/0000-0001-6834-7375)
- Kirsi A. Virtanen (ORCID: https://orcid.org/0000-0001-6183-4525)
- Tobias Fromme (ORCID: https://orcid.org/0000-0001-9150-2513)
- Rikard Landberg (ORCID: https://orcid.org/0000-0002-6399-7608)
- Teemu Saari (ORCID: https://orcid.org/0000-0002-3212-6906)
- Edla Kerminen
Institutions
- Åbo Akademi University (FI)
- University of Turku (FI)
- University of Eastern Finland (FI)
- Turku University Hospital (FI)
- Turku PET Centre (FI)
- Leibniz-Institute for Food Systems Biology at the Technical University of Munich (DE)
- Technical University of Munich (DE)
- Chalmers University of Technology (SE)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1210/clinem/dgaf607
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00