Therapies leading to coronary atherosclerosis plaque regression: a scientific statement of the European Association of Preventive Cardiology, the European Association of Cardiovascular Imaging of the ESC, the ESC Working Group on Atherosclerosis and
Coronary artery disease is one of the leading causes of mortality worldwide. While early identification and treatment of major cardiovascular risk factors are crucial, recent data suggest the possibility of non-invasively detecting early stages of coronary atherosclerosis and potentially stabilizing or even reversing the burden of atherosclerosis with innovative and existing treatments. Moreover, therapies from lipid-lowering to anti-inflammatory drugs were recently demonstrated to influence atherosclerosis progression and potentially lead to different grades of plaque regression. The present is Part 1 of a scientific consensus document divided into two separate manuscripts. This first part provides an up-to-date scientific statement on the pathophysiology mechanism of atherosclerosis progression and regression and on the role of invasive and non-invasive imaging techniques in evaluating and quantifying plaque.
Authors
- Márcio Sommer Bittencourt (ORCID: https://orcid.org/0000-0002-3711-1754)
- Borja Ibáñez (ORCID: https://orcid.org/0000-0002-5036-254X)
- Yoshinobu Onuma (ORCID: https://orcid.org/0000-0001-7702-0649)
- Erwan Donal (ORCID: https://orcid.org/0000-0003-2677-3389)
- Elena Osto (ORCID: https://orcid.org/0000-0001-8196-5696)
- Isabel Gonçalves (ORCID: https://orcid.org/0000-0002-2935-0181)
- Edoardo Conte (ORCID: https://orcid.org/0000-0003-1443-5788)
- Bernard Cosyns (ORCID: https://orcid.org/0000-0001-9419-8019)
- Marc R. Dweck (ORCID: https://orcid.org/0000-0001-9847-5917)
- Francesco Perone (ORCID: https://orcid.org/0000-0002-1418-7908)
- Pál Maurovich‐Horvat (ORCID: https://orcid.org/0000-0003-0885-736X)
- Patrick Washington Serruys
- Juan Carlos Kaski
- Daniele Andreini
Institutions
- Semmelweis University (HU)
- St George's Hospital (GB)
- Vrije Universiteit Brussel (BE)
- Inserm (FR)
- University of Pittsburgh (US)
- University of Milan (IT)
- Medical University of Graz (AT)
- University of Zurich (CH)
- St George’s University Hospitals NHS Foundation Trust (GB)
- University Hospital Galway (IE)
- Université Rennes 2 (FR)
- Lung Institute (US)
- Ospedale San Carlo (IT)
- Istituto Clinico Sant'Ambrogio (IT)
- Universitair Ziekenhuis Brussel (BE)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- Villa Melitta (IT)
- Magnolia Solar (United States) (US)
- Centre Hospitalier Universitaire de Rennes (FR)
- Imperial College London (GB)
- Université de Rennes (FR)
- Universidad Autónoma de Madrid (ES)
- Walden University (US)
- University of Edinburgh (GB)
Publication Details
- Journal
- European Journal of Preventive Cardiology
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1093/eurjpc/zwaf594
- Citations
- 2
- Primary Topic
- Cerebrovascular and Carotid Artery Diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.04