Effect of Aficamten in Women Compared With Men With Obstructive Hypertrophic Cardiomyopathy in SEQUOIA-HCM
Women enrolled in SEQUOIA-HCM were older with worse baseline health status, higher NT-proBNP, and higher left ventricular outflow tract gradients compared with men. Despite these differences, both men and women derived significant benefits in the primary and secondary end points following treatment with aficamten.
Authors
- Roberto Barriales‐Villa (ORCID: https://orcid.org/0000-0002-6721-3487)
- Brian Lee Claggett (ORCID: https://orcid.org/0000-0002-4215-9218)
- Stephen B. Heitner (ORCID: https://orcid.org/0000-0003-2189-1474)
- Maria A. Pabón (ORCID: https://orcid.org/0000-0003-1883-0654)
- Xiaowen Wang (ORCID: https://orcid.org/0000-0002-5374-7832)
- Tracy Makuvire (ORCID: https://orcid.org/0000-0002-1048-311X)
- Sara Saberi (ORCID: https://orcid.org/0000-0003-4473-6725)
- Iacopo Olivotto (ORCID: https://orcid.org/0000-0003-1751-9266)
- Amy Wohltman
- Benjamin Meder (ORCID: https://orcid.org/0000-0003-0741-2633)
- ANJALI TIKU OWENS (ORCID: https://orcid.org/0000-0002-9669-8495)
- Caroline Coats (ORCID: https://orcid.org/0000-0002-3208-470X)
- Scott David Solomon (ORCID: https://orcid.org/0000-0003-3698-9597)
- Martin S. Maron (ORCID: https://orcid.org/0000-0002-9923-3853)
- Daniel Jacoby (ORCID: https://orcid.org/0000-0002-9182-275X)
- Ahmad Masri (ORCID: https://orcid.org/0000-0002-6390-6526)
- Fady I. Malik (ORCID: https://orcid.org/0000-0002-5597-5759)
- Stuart Kupfer (ORCID: https://orcid.org/0000-0002-5469-1287)
- Sheila M. Hegde (ORCID: https://orcid.org/0000-0001-8157-8899)
- Michael E. Nassif (ORCID: https://orcid.org/0000-0002-1232-7604)
- Theodore P. Abraham (ORCID: https://orcid.org/0000-0003-3411-1334)
- Reziwanguli Maimaiti
Institutions
- Brigham and Women's Hospital (US)
- Lahey Hospital and Medical Center (US)
- Saint Luke's Health System (US)
- Harvard University (US)
- Oregon Health & Science University (US)
- University of California, San Francisco (US)
- Heidelberg University (DE)
- University of Michigan (US)
- Lahey Medical Center (US)
- Meyer Children's Hospital (IT)
- Michigan Medicine (US)
- Centro de Investigación Biomédica en Red (ES)
- Saint Luke's Hospital (US)
- Cytokinetics (United States) (US)
- Complexo Hospitalario Universitario A Coruña (ES)
- Institut des Maladies Métaboliques et Cardiovasculaires (FR)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Instituto de Investigación Biomédica de A Coruña (ES)
- University of Glasgow (GB)
- University of Pennsylvania (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Circulation Heart Failure
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1161/circheartfailure.125.013918
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00