Omadacycline as a drug candidate for <i>Mycobacterium avium</i> infections: <i>in vitro</i> insights on single and combination therapies
Omadacycline demonstrated in vitro activity against M. avium, particularly in combination with amikacin. Emergence of clarithromycin and amikacin resistance seemed to be prevented by co-exposure to omadacycline. Further research is warranted to assess omadacycline's role in treating M. avium disease.
Authors
- Jessica V. Pierce
- Corné H. W. Klaassen (ORCID: https://orcid.org/0000-0002-3439-0903)
- Nicole C. Ammerman (ORCID: https://orcid.org/0000-0001-9359-9144)
- Hannelore I. Bax (ORCID: https://orcid.org/0000-0003-0076-5479)
- Saskia E Mudde (ORCID: https://orcid.org/0000-0002-9910-156X)
- Henriëtte M Meliefste
- Jurriaan E. M. de Steenwinkel
Institutions
- Erasmus MC (NL)
- Paratek Pharmaceuticals (United States) (US)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1093/jac/dkaf413
- Citations
- 1
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 1.35