A retrospective observational study of effectiveness of sequential biologic and targeted synthetic DMARDs in psoriatic arthritis in the UK
In this cohort the highest chance of a positive PsARC response was to 1st line b/tsDMARD: twice the chance of response vs 2nd/3rd line. The chance of a positive PsARC response to 4th+ lines of b/tsDMARD was not significantly different from 2nd/3rd lines after adjustment. This indicates that patients in a UK cohort can continue to have a meaningful response to later lines of treatment. This is the first available evidence of response to later lines of b/tsDMARD treatment in PsA.
Authors
- William Tillett (ORCID: https://orcid.org/0000-0001-7531-4125)
- Lija James (ORCID: https://orcid.org/0000-0003-3574-1565)
- Ashley Elliott (ORCID: https://orcid.org/0000-0002-0589-8740)
- Rekha Yadagiri
- Emily Rose‐Parfitt
- Arani Vivekanantham (ORCID: https://orcid.org/0000-0003-4605-6598)
- Tania Gudu (ORCID: https://orcid.org/0000-0002-8973-323X)
- Deepak R. Jadon (ORCID: https://orcid.org/0000-0003-0600-4566)
- Dhivya Das
- Theresa Smith (ORCID: https://orcid.org/0000-0002-7085-3864)
- Nicola Gullick (ORCID: https://orcid.org/0000-0001-8970-4116)
- Gayatri Mittal
- Philip Helliwell (ORCID: https://orcid.org/0000-0002-4155-9105)
- Jon Packham (ORCID: https://orcid.org/0000-0001-5531-1680)
- Emma Williams
- Hoda Mirjafari-Temple
- Neil McHugh (ORCID: https://orcid.org/0000-0003-2765-658X)
- Charlotte E Gollins (ORCID: https://orcid.org/0000-0002-7539-4265)
- Laura C. Coates (ORCID: https://orcid.org/0000-0002-4756-663X)
- Caoimhe Fahy
- Mel Brooke Turfrey (ORCID: https://orcid.org/0000-0003-0914-0088)
- Chetan Chauhan (ORCID: https://orcid.org/0000-0001-7973-0644)
- Ira Pande
- Audrey Russell (ORCID: https://orcid.org/0009-0008-9238-4828)
- Antoni Chan
Institutions
- Royal National Hospital for Rheumatic Diseases (GB)
- University of Leeds (GB)
- Nuffield Orthopaedic Centre (GB)
- University Hospitals Coventry and Warwickshire NHS Trust (GB)
- University of Warwick (GB)
- University of Oxford (GB)
- Research Canada (CA)
- Bath Institute for Rheumatic Diseases (GB)
- University of Bath (GB)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1093/rheumatology/keaf570
- Primary Topic
- Spondyloarthritis Studies and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00