Altered Vascular and Angiogenic Transcripts in the Neurogenic Niche in Neuroinflammatory-Type Schizophrenia
These findings reveal that changes in the BBB and angiogenesis are more severe in high-inflammation schizophrenia and appear to be linked to reduced neurogenesis in the SEZ. This study underscores the importance of inflammation in shaping vascular and neurogenic pathology in schizophrenia, offering potential pathways for future therapeutic exploration.
Authors
- Maree J. Webster (ORCID: https://orcid.org/0000-0002-8778-4148)
- Janice M. Fullerton (ORCID: https://orcid.org/0000-0003-4014-4490)
- Hayley F. North (ORCID: https://orcid.org/0000-0002-8946-6960)
- Cynthia Shannon Weickert (ORCID: https://orcid.org/0000-0002-4560-0259)
- Jessica Fang Yan Lim
Institutions
- The University of Sydney (AU)
- New South Wales Department of Health (AU)
- SUNY Upstate Medical University (US)
- UNSW Sydney (AU)
- Stanley Medical Research Institute (US)
- Schizophrenia Research Institute (AU)
- Neuroscience Research Australia (AU)
Publication Details
- Journal
- Schizophrenia Bulletin
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1093/schbul/sbaf177
- Citations
- 2
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Neuroscience Research Australia
- University of New South Wales
- National Institutes of Health
- Medical Research Council
- National Health and Medical Research Council