HMGCR and Rosuvastatin Regulates GLP-1 Secretion and Expression—A Translational Study
We have established HMGCR as a regulator of GLP-1 secretion and provide a plausible explanation for the clinically observed mild hyperglycemia associated with statin use. Given the negative acute effect on GLP-1 secretion, monitoring of blood glucose levels is recommended after prescribing rosuvastatin."
Authors
- Andreas Lindqvist (ORCID: https://orcid.org/0009-0000-8287-5609)
- Amra Jujić (ORCID: https://orcid.org/0000-0002-9506-0158)
- Peter M. Nilsson (ORCID: https://orcid.org/0000-0002-5652-8459)
- Elaine Cowan (ORCID: https://orcid.org/0000-0003-3939-8864)
- Martin Magnusson (ORCID: https://orcid.org/0000-0003-1710-5936)
- Rita Del Giudice
- Dmytro Kryvokhyzha (ORCID: https://orcid.org/0000-0001-6498-1977)
- Lena Eliasson (ORCID: https://orcid.org/0000-0002-6467-5029)
- Signe S. Torekov (ORCID: https://orcid.org/0000-0001-6779-0252)
- Sweta Raikundalia (ORCID: https://orcid.org/0000-0003-4604-153X)
- Michael G. Miskelly (ORCID: https://orcid.org/0000-0002-4688-5719)
- Maria F. Gomez (ORCID: https://orcid.org/0000-0001-6210-3142)
- Nils Wierup (ORCID: https://orcid.org/0000-0001-6824-4093)
- Jens O. Lagerstedt
- Jens J. Holst (ORCID: https://orcid.org/0000-0001-6853-3805)
- Jan Hedenbro (ORCID: https://orcid.org/0000-0001-7479-9087)
- Hindrik Mulder (ORCID: https://orcid.org/0000-0002-6593-8417)
- Anna-Maria Dutius Andersson
- Alexander Hamilton (ORCID: https://orcid.org/0000-0001-5203-9220)
- Bent-Johnny Nergård
Institutions
- University of Copenhagen (DK)
- Malmö University (SE)
- Lund University (SE)
- Novo Nordisk Foundation (DK)
- Skåne University Hospital (SE)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1210/clinem/dgaf608
- Citations
- 2
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 2.59
Funders
- Eli Lilly and Company
- Pfizer
- Bayer
- Sanofi
- Juvenile Diabetes Research Foundation United States of America
- European Federation of Pharmaceutical Industries and Associations
- European Commission
- Stiftelsen för Strategisk Forskning
- Lunds Universitet
- Novo Nordisk
- Vetenskapsrådet
- Astellas Pharma
- Kungliga Fysiografiska Sällskapet i Lund
- Direktör Albert Påhlssons Stiftelse
- Horizon 2020 Framework Programme