Physical Activity and Cardiovascular Outcomes in Phenotype-Negative Cardiomyopathy Variant Carriers
In this cohort study, MVPA within the general range of guideline-based recommendations was associated with lower risk of adverse CV outcomes and similar degrees of cardiac remodeling for G+P- carriers compared to noncarriers. Findings support the appropriateness of guideline-based MVPA recommendations for G+P- carriers.
Authors
- James P. Pirruccello (ORCID: https://orcid.org/0000-0001-6088-4037)
- Victor Nauffal (ORCID: https://orcid.org/0000-0001-7199-299X)
- Shaan Khurshid (ORCID: https://orcid.org/0000-0002-2840-4539)
- Seung Hoan Choi (ORCID: https://orcid.org/0000-0002-2797-3190)
- Krishna G. Aragam (ORCID: https://orcid.org/0000-0003-3223-9131)
- James Sawalla Guseh (ORCID: https://orcid.org/0000-0003-0992-5635)
- Neal K. Lakdawala (ORCID: https://orcid.org/0000-0001-6458-5421)
- Ezimamaka Ajufo (ORCID: https://orcid.org/0000-0001-5330-0144)
- Timothy W. Churchill (ORCID: https://orcid.org/0000-0002-0215-3049)
- Patrick T. Ellinor (ORCID: https://orcid.org/0000-0002-2067-0533)
- Shinwan Kany
- Sean J. Jurgens (ORCID: https://orcid.org/0000-0002-1605-9782)
- Carolyn Y. Ho
Institutions
- Broad Institute (US)
- Boston University (US)
- Heart Rhythm Society (US)
- Universität Hamburg (DE)
- University of California, San Francisco (US)
- University Medical Center Hamburg-Eppendorf (DE)
- Amsterdam University Medical Centers (NL)
- Mass General Brigham (US)
Publication Details
- Journal
- JAMA Cardiology
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1001/jamacardio.2025.4466
- Citations
- 1
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.39