ICOS signaling is involved in the development of allergic rhinitis by regulating the differentiation of T cells, especially Th2 cells
Our findings demonstrate that ICOS expression and effects are linked to the differentiation of T cells in AR, especially Th2 cells, which suggests ICOS-expressing Th2 cells as a potential therapeutic target for AR.
Authors
- Yafeng Yu (ORCID: https://orcid.org/0000-0003-3558-0263)
- Qingqing Jiao (ORCID: https://orcid.org/0000-0001-6278-2608)
- Qian Gao (ORCID: https://orcid.org/0009-0005-2412-5777)
- Zhi Xiao (ORCID: https://orcid.org/0009-0000-9300-3312)
- Michael W. Cheng (ORCID: https://orcid.org/0000-0002-1869-2557)
Institutions
- Soochow University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Traditional Chinese Medicine Hospital of Kunshan (CN)
- Suzhou Traditional Chinese Medicine Hospital (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Allergology International
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1016/j.alit.2025.10.003
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00