Synthesis of Pentafluoroethylated Heterocycles via Cycloaddition of Dipoles With Pentafluoropropanenitrile Derived From R115
ABSTRACT The base‐promoted in situ generation of pentafluoropropanenitrile from pentafluoropropanal O ‐(2,4‐dinitrophenyl) oxime derived from R115 has been developed. The pentafluoropropanenitrile obtained by this methodology was employed as a highly reactive electrophilic reagent in a cycloaddition reaction with a variety of dipoles to afford pentafluoroethylated heterocycles in moderate to excellent yields.
Authors
- Yangjie Huang (ORCID: https://orcid.org/0000-0001-6030-0097)
- Renning Dong (ORCID: https://orcid.org/0000-0002-0918-6492)
- Biqiong Hong
- Zhiqiang Weng (ORCID: https://orcid.org/0000-0001-6851-1841)
- Jingyi Zhang (ORCID: https://orcid.org/0000-0001-6490-4963)
- Xiaoyan Han (ORCID: https://orcid.org/0000-0002-2113-3801)
- Lili Xie (ORCID: https://orcid.org/0009-0003-4173-9741)
Institutions
- Minjiang University (CN)
- Soochow University (CN)
- Fuzhou University (CN)
Publication Details
- Journal
- Asian Journal of Organic Chemistry
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1002/ajoc.70248
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00