Baseline Characteristics of the TOPaZ Study: Randomised Trial of Teriparatide and Zoledronic Acid Compared with Standard Care in Adults with Osteogenesis Imperfecta
The TOPaZ population represents a unique cohort with which to study the genetic epidemiology and outcome of OI in relation to bone density and biochemical markers of bone turnover. When the trial reports, it will also provide new insights into the effect of an anabolic therapy, followed by antiresorptive treatment in the management of OI.
Authors
- Geeta Hampson (ORCID: https://orcid.org/0000-0001-8465-5247)
- Holly A. Black (ORCID: https://orcid.org/0000-0003-3250-2665)
- Christopher John Weir (ORCID: https://orcid.org/0000-0002-6494-4903)
- Jennifer Walsh (ORCID: https://orcid.org/0000-0002-7122-2650)
- Jonathan Tang (ORCID: https://orcid.org/0000-0001-6305-6333)
- Rachel Crowley (ORCID: https://orcid.org/0000-0003-1472-4117)
- Navnit S. Makaram (ORCID: https://orcid.org/0000-0003-4227-8361)
- Terry Aspray (ORCID: https://orcid.org/0000-0001-9522-6069)
- Robin Munro
- Rosemary Hollick (ORCID: https://orcid.org/0000-0001-6558-7189)
- Patricia A. Osborne
- Zoé Paskins (ORCID: https://orcid.org/0000-0002-7783-2986)
- John R. Lindsay (ORCID: https://orcid.org/0000-0003-1036-8477)
- Jannie Dahl Hald (ORCID: https://orcid.org/0000-0002-7907-3792)
- Prashanth Patel (ORCID: https://orcid.org/0000-0002-8981-2691)
- Stuart H. Ralston (ORCID: https://orcid.org/0000-0002-2804-7586)
- Nazim Ghouri (ORCID: https://orcid.org/0000-0002-8263-2591)
- Morag MacLean (ORCID: https://orcid.org/0000-0002-4037-0247)
- Elizabeth Malcolm (ORCID: https://orcid.org/0000-0001-9691-4592)
- Deepa Narayanan (ORCID: https://orcid.org/0000-0002-0401-8844)
- Nicholas C. Harvey (ORCID: https://orcid.org/0000-0002-8194-2512)
- Martine Cohen‐Solal (ORCID: https://orcid.org/0000-0002-8582-8258)
- Kenneth Poole (ORCID: https://orcid.org/0000-0002-9187-9967)
- Mike Stone (ORCID: https://orcid.org/0000-0003-1568-9560)
- Richard Keen (ORCID: https://orcid.org/0009-0001-8216-3828)
- Jane F. Turton (ORCID: https://orcid.org/0000-0001-5652-6472)
- M K Javaid (ORCID: https://orcid.org/0000-0001-7985-0048)
- Bente Langdahl (ORCID: https://orcid.org/0000-0002-8712-7199)
- Zaki Hassan‐Smith
- Elisabeth M. W. Eekhoff (ORCID: https://orcid.org/0000-0001-5399-676X)
- Catriona Keerie (ORCID: https://orcid.org/0000-0001-5459-6178)
- Stephen Tuck (ORCID: https://orcid.org/0000-0001-5060-4214)
- Elizabeth Curtis (ORCID: https://orcid.org/0000-0002-5147-0550)
- Andrew David Duckworth (ORCID: https://orcid.org/0000-0002-5317-1300)
- David Moore (ORCID: https://orcid.org/0000-0001-9308-5741)
- Gordon B. Stenhouse (ORCID: https://orcid.org/0000-0003-4551-4585)
- Mashood Siddiqi
- Lorna Dewar
- Wayne Lam
- Johannes Feenstra
- Matthew Roy
- Tianyu Guo
- Lynsey Milne
Institutions
- University College Dublin (IE)
- Belfast Health and Social Care Trust (GB)
- National Health Service Scotland (GB)
- NHS Lothian (GB)
- University of Liverpool (GB)
- Inserm (FR)
- Aston University (GB)
- University of Aberdeen (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Queen Elizabeth Hospital Birmingham (GB)
- Musgrave Park Hospital (GB)
- NHS Education for Scotland (GB)
- Hull University Teaching Hospitals NHS Trust (GB)
- Western General Hospital (GB)
- University Hospitals Bristol NHS Foundation Trust (GB)
- Nuffield Orthopaedic Centre (GB)
- Wishaw General Hospital (GB)
- Freeman Hospital (GB)
- Aarhus University Hospital (DK)
- University Hospitals of Leicester NHS Trust (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Ninewells Hospital (GB)
- Edinburgh Cancer Research (GB)
- Royal Liverpool University Hospital (GB)
- Edinburgh Royal Infirmary (GB)
- Bristol Royal Infirmary (GB)
- South Tees Hospitals NHS Foundation Trust (GB)
- University of Oxford (GB)
- Netherlands Center for Occupational Diseases (NL)
- Cancer Trials Ireland (IE)
- St. Vincent's University Hospital (IE)
- NIHR Southampton Biomedical Research Centre (GB)
- Bioscar (FR)
- Royal National Orthopaedic Hospital NHS Trust (GB)
- Brittle Bone Society (GB)
- British Biophysical Society (GB)
- Isala (NL)
- University Hospital Llandough (GB)
- MRC Lifecourse Epidemiology Unit (GB)
- Addenbrooke's Hospital (GB)
- Queen Elizabeth University Hospital (GB)
- University of Southampton (GB)
- University College London (GB)
- Keele University (GB)
- University of Sheffield (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Calcified Tissue International
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1007/s00223-025-01440-3
- Primary Topic
- Connective tissue disorders research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eli Lilly and Company
- National Institute for Health and Care Research
- Medical Research Council