Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial
Sibeprenlimab resulted in a significant reduction in proteinuria as compared with placebo in patients with IgA nephropathy. (Funded by Otsuka Pharmaceutical Development and Commercialization. VISIONARY ClinicalTrials.gov number, NCT05248646.).
Authors
- Dana V. Rizk (ORCID: https://orcid.org/0000-0002-6877-2811)
- Lokesh Shah (ORCID: https://orcid.org/0000-0002-8811-9617)
- Michael Walsh (ORCID: https://orcid.org/0000-0001-8292-2014)
- Laura Kooienga
- Hong Zhang (ORCID: https://orcid.org/0000-0003-4179-5666)
- Chee Kay Cheung (ORCID: https://orcid.org/0000-0001-8593-7625)
- Seung Hyeok Han (ORCID: https://orcid.org/0000-0001-7923-5635)
- Manisha Sahay (ORCID: https://orcid.org/0000-0001-5534-2516)
- Vivekanand Jha (ORCID: https://orcid.org/0000-0002-8015-9470)
- Adrian Liew (ORCID: https://orcid.org/0000-0002-0963-6270)
- Muh Geot Wong (ORCID: https://orcid.org/0000-0002-7575-9877)
- Manuel Praga (ORCID: https://orcid.org/0000-0001-9270-1071)
- Bobby Chacko (ORCID: https://orcid.org/0000-0002-0292-5512)
- Jonathan Barratt (ORCID: https://orcid.org/0000-0002-9063-7229)
- Kevin Carroll (ORCID: https://orcid.org/0000-0002-3500-9692)
- Cecile Fajardo
- Richard Lafayette (ORCID: https://orcid.org/0000-0003-3906-7934)
- Hernán Trimarchi (ORCID: https://orcid.org/0000-0002-6921-4811)
- Yusuke Suzuki (ORCID: https://orcid.org/0000-0002-4077-9747)
- Jeffrey Hafkin (ORCID: https://orcid.org/0000-0002-6690-3240)
- Vladimı́r Tesař (ORCID: https://orcid.org/0000-0001-6982-0689)
- Jing Xia (ORCID: https://orcid.org/0009-0005-6602-8334)
- Vlado Perkovic
- Alejandra Quevedo
Institutions
- Universidad Complutense de Madrid (ES)
- Hospital Británico (UY)
- University of Leicester (GB)
- Manipal Academy of Higher Education (IN)
- Yonsei University (KR)
- Peking University (CN)
- Charles University (CZ)
- Concord Repatriation General Hospital (AU)
- John Hunter Hospital (AU)
- Osmania General Hospital (IN)
- Mount Elizabeth Novena Hospital (SG)
- Population Health Research Institute (CA)
- UNSW Sydney (AU)
- University of Alabama at Birmingham (US)
- Juntendo University (JP)
- Otsuka (United States) (US)
- Clínica Rementería (ES)
- Priory Hospital Cheadle Royal (GB)
- Peking University First Hospital (CN)
- Stanford Medicine (US)
- George Institute for Global Health (IN)
- Colorado Kidney Care (US)
- Imperial College London (GB)
- Hamilton Health Sciences (CA)
- Stanford University (US)
- McMaster University (CA)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1056/nejmoa2512133
- Citations
- 14
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 20.03