Collagenolytic Enterococcus faecalis induces DDR1 signaling, proliferation and altered immune infiltrate in colorectal peritoneal metastases
Collagenolytic <i>E. faecalis</i> induce DDR1 pathway activation in CRC cells, alter the immune landscape in mouse models, and are enriched in human CRC peritoneal metastases. Further work is required to determine whether eradication of intratumoral bacteria can change tumor biology.
Authors
- Ramani Soundararajan (ORCID: https://orcid.org/0000-0001-6408-2840)
- Hariom Yadav (ORCID: https://orcid.org/0000-0003-4504-1597)
- Jason B. Fleming (ORCID: https://orcid.org/0000-0002-8796-5627)
- Seán Dineen (ORCID: https://orcid.org/0000-0002-2012-2238)
- John E. Mullinax (ORCID: https://orcid.org/0000-0002-9596-6785)
- Michelle M. Maurin (ORCID: https://orcid.org/0009-0005-4777-2504)
- Andreas Karachristos (ORCID: https://orcid.org/0000-0001-5773-5209)
- Richard A. Jacobson (ORCID: https://orcid.org/0000-0002-3432-5378)
- Sidharth P. Mishra (ORCID: https://orcid.org/0000-0001-7586-846X)
- Timothy M. Nywening
- Rainer de Martin
- Timothy Joseph Yeatman (ORCID: https://orcid.org/0000-0002-7487-0784)
Institutions
- University of South Florida (US)
- Tampa General Hospital (US)
- Moffitt Cancer Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Surgery Open Science
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1016/j.sopen.2025.10.011
- Citations
- 1
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.23
Funders
- American Society for Parenteral and Enteral Nutrition
- American Society for Parenteral and Enteral Nutrition Rhoads Research Foundation