Impact of target volume and dose concepts on the outcomes of prostate cancer patients treated with stereotactic body radiotherapy for spinal metastases − a European multicenter cohort study
This multicenter cohort analysis showed that SBRT of spine BoM from prostate cancer is an effective and well-tolerated treatment. Both BED and usage of a SIB concept were associated with improved PFS and BRFS. Prospective studies are needed to confirm these findings and further standardize SBRT concepts.
Authors
- Sophia Drabke
- Richard Partl (ORCID: https://orcid.org/0000-0001-9132-012X)
- Olaf Wittenstein (ORCID: https://orcid.org/0000-0003-4127-3139)
- Matthias Gückenberger (ORCID: https://orcid.org/0000-0002-7146-9071)
- Kenneth Klischies
- Richard Holý (ORCID: https://orcid.org/0000-0003-1112-6197)
- Maike Trommer (ORCID: https://orcid.org/0000-0003-2864-4273)
- Christos Moustakis (ORCID: https://orcid.org/0000-0002-8879-2350)
- Ahmed Gawish (ORCID: https://orcid.org/0000-0001-5557-7438)
- Yvonne Dzierma (ORCID: https://orcid.org/0000-0003-4414-9571)
- S. A. Schafer (ORCID: https://orcid.org/0009-0004-3790-3278)
- Fabian Lohaus (ORCID: https://orcid.org/0000-0003-4043-7066)
- Lucas Kastner (ORCID: https://orcid.org/0000-0001-5839-5461)
- Thomas Mader (ORCID: https://orcid.org/0009-0006-1834-7602)
- Oliver Blanck (ORCID: https://orcid.org/0000-0003-1391-1308)
- Jochen Willner
- Judit Boda‐Heggemann (ORCID: https://orcid.org/0000-0002-5831-0197)
- Alexander Rühle (ORCID: https://orcid.org/0000-0003-2022-897X)
- Priska Bank
- Camilla von Wachter
- Panagiotis Balermpas (ORCID: https://orcid.org/0000-0001-5261-6446)
- M Slavík (ORCID: https://orcid.org/0000-0002-8591-5941)
- Arne Grün (ORCID: https://orcid.org/0000-0002-3868-2719)
- Felix Ehret (ORCID: https://orcid.org/0000-0001-6177-1755)
- Thomas Brunner (ORCID: https://orcid.org/0000-0002-6780-2820)
- Jörg Andreas Müller (ORCID: https://orcid.org/0000-0003-0843-7373)
- Nils H. Nicolay (ORCID: https://orcid.org/0000-0003-2550-1410)
- Petr Burkoň (ORCID: https://orcid.org/0000-0002-9863-9376)
- Franziska Nägler
- Andrea Baehr
- Isabell Seiler
- Andrea Glasmacher
- Johannes Meents (ORCID: https://orcid.org/0009-0006-0636-4296)
- Anna Sabrina Schunn (ORCID: https://orcid.org/0009-0003-9421-8456)
Institutions
- Universität Hamburg (DE)
- Philipps University of Marburg (DE)
- Johannes Gutenberg University Mainz (DE)
- Medical University of Graz (AT)
- Masaryk University (CZ)
- Heidelberg University (DE)
- University Hospital Bonn (DE)
- University Hospital Heidelberg (DE)
- Bayreuth Medical Center (DE)
- Humboldt-Universität zu Berlin (DE)
- Düsseldorf University Hospital (DE)
- Comprehensive Cancer Center Vienna (AT)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- SRH Wald-Klinikum Gera (DE)
- Integrated Oncology (United States) (US)
- University Hospital of Zurich (CH)
- University Medical Center Hamburg-Eppendorf (DE)
- University Hospital Schleswig-Holstein (DE)
- Masaryk Memorial Cancer Institute (CZ)
- Universitätsklinikum Aachen (DE)
- University Hospital Leipzig (DE)
- Kantonsspital Graubünden (CH)
- University Hospital in Halle (DE)
- University Medical Centre Mannheim (DE)
- University Hospital Carl Gustav Carus (DE)
- Heinrich Heine University Düsseldorf (DE)
- University of Rostock (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Lübeck (DE)
- FH Aachen (DE)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1016/j.radonc.2025.111276
- Citations
- 1
- Primary Topic
- Management of metastatic bone disease
- Type
- article
- Field-Weighted Citation Impact
- 2.01